F. Zahedifard

Beyond the VSG Layer: Exploring the Role of Intrinsic Disorder in the Invariant Surface Glycoproteins of African Trypanosomes

This study investigates the role of intrinsic disorder in invariant surface glycoproteins (ISGs) of African trypanosomes, showing they can switch between compact and elongated conformers to balance immune evasion and host interaction.

Targeted protein degradation of the CPSF complex by benzoxaboroles through sumoylation

This study identifies CPSF3 as a target of benzoxaboroles in trypanosomatids, showing that BoBs induce sumoylation-dependent degradation of CPSF complex members, leading to reduced mRNA levels.

Repurposing of mitochondria-targeted tamoxifen: Novel anti-cancer drug exhibits potent activity against major protozoan and fungal pathogens.

This paper demonstrates that MitoTam, a mitochondria-targeted tamoxifen analog, effectively kills various pathogens including fungi, Plasmodium falciparum, and trypanosomatid parasites in vitro and in vivo.