HIV-1 hijacks the cell extracellular matrix to spread collectively and efficiently between T lymphocytes
C. Inizan, M. Caillet, A. Desrames, P. Bomme, A. MALLET, K. Bourdic, O. Lambotte, F. Boufassa, M. Mesel-Lemoine, F. Tangy, G. Pancino, H. Mouquet, t. Lagache, A. C. Dufour, J.-C. Olivo-Marin, , M.-I. Thoulouze
This study shows HIV-1 spreads between T lymphocytes via extracellular matrix (ECM)-clustered viral particles, enhancing transmission efficiency and resistance to antiretroviral treatment and antibodies.
bioRxiv · Sep 27, 2021 · PreprintMicrobiology