F. A. Rey

Modulation of SARS-CoV-2 spike binding to ACE2 throughconformational selection

This study uses single-molecule techniques to show that SARS-CoV-2 spike protein RBD dynamics modulate ACE2 binding through conformational selection without affecting unbinding.

Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus

This study determines the structure of HKU1-CoV receptor binding domain in complex with TMPRSS2, identifying key residues for host tropism and revealing the structural basis of TMPRSS2 activation.

On the Role of VP3-PI3P Interaction in Birnavirus Endosomal Membrane Targeting

This paper investigates how VP3 protein of birnaviruses targets endosomal membranes via PI3P binding, revealing a two-stage mechanism critical for viral replication.

Structures of the Foamy virus fusion protein reveal an unexpected link with the F protein of paramyxo- and pneumoviruses

The paper reports cryo-EM structures of foamy virus Env in pre- and post-fusion states, revealing structural similarity to paramyxovirus F proteins and suggesting an evolutionary link.

A synthetic delivery vector for mucosal vaccination

This paper develops a synthetic delivery vector for mucosal vaccination that induces mucosal immunity and CD8+ T cell responses in mice.

Omicron BA.1 breakthrough infection drives long-term remodeling of the memory B cell repertoire in vaccinated individuals.

This study shows that Omicron BA.1 breakthrough infection in vaccinated individuals leads to long-term remodeling of memory B cells, enhancing neutralizing breadth and potency against common and BA.1 epitopes but not BA.5.

Molecular mechanisms regulating the pH-dependent pr/E interaction in yellow fever virus.

This study shows that yellow fever virus pr retains high affinity for E at neutral pH, differing from other flaviviruses, and reveals a unique mechanism for pr release from mature particles.

Neutralization of zoonotic retroviruses by human antibodies: genotype-specific epitopes within the receptor-binding domain from simian foamy virus

This study identifies genotype-specific epitopes in the receptor-binding domain of simian foamy virus that are targeted by neutralizing antibodies, revealing mechanisms of immune evasion and neutralization.

The crystal structure of a simian Foamy Virus receptor binding domain provides clues about entry into host cells

The paper determines the X-ray structure of a simian Foamy Virus receptor binding domain, revealing its fold and key residues involved in heparan sulfate interaction.

Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies

This study maps antigenic sites and characterizes neutralizing antibodies against hantaviruses, identifying mechanisms and cross-protective potential for vaccine development.

Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

The paper identifies potent broadly neutralizing IgA and IgG antibodies against SARS-CoV-2 variants, including Omicron BA.1 and BA.2, from memory B cells in convalescents.

Immune escape of SARS-CoV-2 Omicron variant from mRNA vaccination-elicited RBD-specific memory B cells.

The paper assesses how well mRNA vaccine-induced memory B cells recognize the Omicron variant of SARS-CoV-2 and finds that Omicron evades recognition more than previous variants.

HIV-1 hijacks the cell extracellular matrix to spread collectively and efficiently between T lymphocytes

This study shows HIV-1 spreads between T lymphocytes via extracellular matrix (ECM)-clustered viral particles, enhancing transmission efficiency and resistance to antiretroviral treatment and antibodies.

Memory B cells control SARS-CoV-2 variants upon mRNA vaccination of naive and COVID-19 recovered individuals.

The study compares memory B cell responses in naive and recovered individuals after mRNA vaccination, showing enhanced expansion and neutralization against variants in recovered patients.

The dengue virus NS1 protein conveys pro-inflammatory signals by docking onto human high-density lipoproteins

This study identifies NS1-dengue virus protein's interaction with human HDL as a mechanism to trigger pro-inflammatory signals during infection.

Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling

This study identifies how HHV-8 uses molecular mimicry of ephrin ligands to bind EphA2, triggering signaling that facilitates viral entry and cytoskeleton remodeling.

Maturation and persistence of the anti-SARS-CoV-2 memory B cell response.

This study tracks the maturation of SARS-CoV-2-specific memory B cells over 6 months, showing their persistence and mutation accumulation.

The generation of plasma cells and CD27-IgD- B cells during Hantavirus infection are associated with distinct pathological findings

This study links plasma cell and CD27-IgD- B cell generation during Hantavirus infection to distinct pathological features in HFRS.