H. Mouquet

Comprehensive Analysis of Neutrophil Immunomodulatory Properties and FcR Dynamics in Health and HIV-1 Infection and Therapy

The paper examines neutrophil immunomodulatory properties and FcR dynamics in HIV-1 infection and therapy, finding altered cytokine production and FcR expression in PLWH.

High fusion and cytopathy of SARS-CoV-2 variant B.1.640.1

This study characterizes the high fusogenicity and cytopathic effects of the SARS-CoV-2 B.1.640.1 variant, identifying mutations in the spike S2 domain responsible for these properties.

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies

This study evaluates the neutralizing antibody resistance of SARS-CoV-2 Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 to monoclonal antibodies and sera from vaccinated individuals.

SARS-CoV-2 infection in domestic rats after transmission from their infected owner

This study shows SARS-CoV-2 Omicron can infect domestic rats, with one developing severe symptoms, suggesting rodents may contribute to viral spread and evolution.

Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of SARS-CoV-2

The paper investigates how the SARS-CoV-2 spike protein's interaction with ACE2 evolved, revealing changes in binding dynamics and physicochemical forces across variants.

IRF8 regulates efficacy of therapeutic anti-CD20 monoclonal antibodies

This study identifies IRF8 as a regulator of CD20 expression and anti-CD20 antibody efficacy through CRISPR screening and functional validation in B cells.

Somatic hypermutation patterns in immunoglobulin variable regions are established independently of the local transcriptional landscape

The paper examines SHM patterns in immunoglobulin variable regions and finds they are not significantly correlated with local transcriptional features.

The spike-stabilizing D614G mutation interacts with S1/S2 cleavage site mutations to promote the infectious potential of SARS-CoV-2 variants

This study shows the D614G mutation enhances the infectious potential of SARS-CoV-2 variants by synergizing with cleavage site mutations like P681H/R to increase spike fusogenicity.

Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody

The paper evaluates the potency of mAb J08 against SARS-CoV-2 variants using cell-based assays and cryo-EM, showing its resistance to escape mutations and broad binding capability.

Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

The paper identifies potent broadly neutralizing IgA and IgG antibodies against SARS-CoV-2 variants, including Omicron BA.1 and BA.2, from memory B cells in convalescents.

An intranasal lentiviral booster broadens immune recognition of SARS-CoV-2 variants and reinforces the waning mRNA vaccine-induced immunity that it targets to lung mucosa

This study shows an intranasal lentiviral booster enhances and broadens immune response to SARS-CoV-2 variants and improves waning mRNA vaccine immunity in the lungs.

Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2

This study examines the fusogenicity and neutralization sensitivity of the SARS-CoV-2 AY.4.2 sublineage compared to the Delta variant, finding similar spike function but reduced neutralization sensitivity to certain antibodies and vaccines.

Considerable escape of SARS-CoV-2 variant Omicron to antibody neutralization

This study shows that the Omicron variant of SARS-CoV-2 is resistant to most monoclonal antibodies and vaccine-induced antibodies, with reduced neutralization compared to Delta.

HIV-1 hijacks the cell extracellular matrix to spread collectively and efficiently between T lymphocytes

This study shows HIV-1 spreads between T lymphocytes via extracellular matrix (ECM)-clustered viral particles, enhancing transmission efficiency and resistance to antiretroviral treatment and antibodies.

SARS-CoV-2 Alpha, Beta and Delta variants display enhanced Spike-mediated Syncytia Formation

This study compares syncytia formation by SARS-CoV-2 Alpha, Beta, and Delta variants to D614G, finding enhanced fusogenicity and differential effects of mutations on ACE2 binding and antibody escape.

Reduced sensitivity of infectious SARS-CoV-2 variant B.1.617.2 to monoclonal antibodies and sera from convalescent and vaccinated individuals

This study shows that the SARS-CoV-2 B.1.617.2 variant is less sensitive to monoclonal antibodies and sera from convalescent and vaccinated individuals compared to other variants.

Variants with the N501Y mutation extend SARS-CoV-2 host range to mice, with contact transmission

The paper shows that SARS-CoV-2 variants with the N501Y mutation can infect and transmit to mice, suggesting potential for rodent reservoirs.

A monocyte/dendritic cell molecular signature of SARS-CoV2-related multisystem inflammatory syndrome in children (MIS-C) with severe myocarditis

The paper identifies a monocyte/dendritic cell gene signature in severe MIS-C with myocarditis, linked to NF-κB activity and cytokine signaling.

Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies

This study assesses the neutralization sensitivity of SARS-CoV-2 B.1.1.7 and B.1.351 variants compared to D614G using sera and nasal swabs, finding reduced efficacy against B.1.351 in some convalescent and vaccinated individuals.

Syncytia formation by SARS-CoV-2 infected cells

This study shows SARS-CoV-2 infected cells form syncytia via Spike protein-mediated fusion, regulated by IFITMs and TMPRSS2.

Intranasal Vaccination with a Lentiviral Vector Strongly Protects against SARS-CoV-2 in Mouse and Golden Hamster Preclinical Models

This study shows that intranasal vaccination with a lentiviral vector encoding the SARS-CoV-2 Spike protein provides strong protection against SARS-CoV-2 in mice and golden hamsters by reducing viral load and inflammation.