Enhancing Hepatic MBOAT7 Expression Does Not Improve Nonalcoholic Steatohepatitis in Mice
M. C. Sharpe, K. D. Pyles, T. Hallcox, D. R. Kamm, M. Piechowski, B. Fisk, C. J. Albert, D. H. Carpenter, B. Ulmasov, D. A. Ford, B. A. Neuschwander-Tetri, K. S. McCommis
This study shows that increasing MBOAT7 expression in mice with NASH does not significantly improve liver histology, likely due to low arachidonoyl-CoA substrate levels.
bioRxiv · Mar 24, 2022 · PreprintPathology