Author

N. Rouphael

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Assay:proteomics· 3 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

L. Lai· 4 shared M. S. Suthar· 4 shared D. C. Douek· 3 shared E. J. Anderson· 3 shared J. Wrammert· 3 shared M. E. Davis-Gardner· 3 shared S. Godbole· 3 shared A. Moreno· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersImmunology

L. Lai

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

XBB.1.5 monovalent booster improves antibody binding and neutralization against emerging SARS-CoV-2 Omicron variants

S. Jain, S. Kumar, L. Lai, S. Linderman, A. A. Malik, M. L. Ellis, S. Godbole, D. Solis, M. K. Sahoo, K. Bechnak, I. Paredes, R. Tanios, B. Kazzi, S. M. Dib, M. B. Litvack, , M. S. Suthar

The paper evaluates the effectiveness of an XBB.1.5 monovalent booster vaccine, showing improved antibody binding and neutralization against SARS-CoV-2 Omicron variants.

bioRxiv · Feb 3, 2024 · PreprintImmunology

Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants

J. P. Gygi, C. Maguire, R. K. Patel, P. Shinde, A. Konstorum, C. P. Shannon, L. Xu, A. Hoch, N. Jayavelu, IMPACC Network, E. K. Haddad, E. F. Reed, M. Kraft, G. A. McComsey, J. Metcalf, , Pete

This study identifies immune programs linked to COVID-19 severity and mortality through longitudinal multi-omics analysis of 1,152 hospitalized patients.

bioRxiv · Nov 3, 2023Immunology

mRNA bivalent booster enhances neutralization against BA.2.75.2 and BQ.1.1

M. E. Davis-Gardner, L. Lai, B. Wali, H. Samaha, D. Solis, M. Lee, A. Porter-Morrison, I. T. Hentenaar, F. Yamamoto, S. Godbole, D. C. Douek, F. E.-H. Lee, N. Rouphael, A. Moreno, B. A. Pinsky, M. S. Suthar

This study evaluates the neutralizing efficacy of bivalent mRNA boosters against emerging SARS-CoV-2 subvariants BA.2.75.2 and BQ.1.1, showing improved protection compared to monovalent boosters.

bioRxiv · Oct 31, 2022 · PreprintImmunology

mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 Omicron variant

V.-V. Edara, K. E. Manning, M. Ellis, L. Lai, K. M. Moore, S. L. Foster, K. Floyd, M. E. Davis-Gardner, G. Mantus, L. E. Nyhoff, S. Bechnack, G. Alaaeddine, A. Naji, H. Samaha, M. Lee, , M. S. Suthar

This study evaluates the neutralizing activity of mRNA vaccines against the SARS-CoV-2 Omicron variant, showing reduced efficacy after the second dose but improved responses following a third dose.

bioRxiv · Dec 20, 2021Immunology

Reduced binding and neutralization of infection- and vaccine-induced antibodies to the B.1.351 (South African) SARS-CoV-2 variant

V. V. Edara, C. Norwood, K. Floyd, L. Lai, M. E. Davis-Gardner, W. H. Hudson, G. Mantus, L. E. Nyhoff, M. W. Adelman, R. Fineman, S. Patel, R. Byram, D. N. Gomes, G. Michael, H. Abdullahi, , M. S. Suthar

The paper compares antibody binding and neutralization against SARS-CoV-2 B.1 and B.1.351 variants in infected and vaccinated individuals, finding reduced titers but retained neutralization.

bioRxiv · Feb 20, 2021 · PreprintImmunology

Alterations in the human plasma lipidome in response to Tularemia vaccination

K. Maner-Smith, D. A. Ford, J. B. Goll, M. Khadka, T. L. Jensen, J. K. Colucci, C. E. Gelber, C. J. Albert, S. E. Bosinger, J. D. Franke, M. Natrajan, N. Rouphael, R. A. Johnson, P. Sanz, E. J. Anderson, , E. A. Ortlund

This study identifies changes in the plasma lipidome after tularemia vaccination, highlighting key lipid species and their association with inflammation and immune response.

bioRxiv · Mar 16, 2020Biochemistry