Structure-guided engineering of a fast genetically encoded sensor for real-time H2O2 monitoring.
Justin Daho Lee, Woojin Won, Kandace Kimball, Yihan Wang, Fred Yeboah, Kira M. Evitts, Carlie Neiswanger, Selena Schattauer, Michael Rappleye, Samantha B Bremner, Changho Chun, Netta Smith, David L. Mack, Jessica E. Young, C. Justin Lee, , Andre Berndt
This paper develops a fast, sensitive genetically encoded H2O2 sensor (oROS-G) and demonstrates its use in monitoring H2O2 dynamics in various cell types and models.
bioRxiv · Jan 31, 2024 · PreprintBioengineering