Human mutations in high-confidence Tourette disorder genes affect sensorimotor behavior, reward learning, and striatal dopamine in mice
Cara Nasello, Lauren A. Poppi, Junbing Wu, Tess F. Kowalski, Joshua K. Thackray, Riley Wang, Angelina Persaud, Mariam Mahboob, Sherry Lin, Rodna Spaseska, C. K. Johnson, Derek Gordon, Fadel Tissir, Gary A. Heiman, Jay A. Tischfield, , Max A. Tischfield
The paper generates mouse models with human mutations in TD genes, showing sensorimotor and reward learning phenotypes, dopamine changes, and sex-specific effects.
Proceedings of the National Academy of Sciences · Apr 29, 2024Peer-reviewedNeuroscience