Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence
S. A. Haws, D. Yu, C. Ye, C. K. Wille, L. C. Nguyen, K. A. Krautkramer, J. L. Tomasiewicz, S. E. Yang, B. R. Miller, W. H. Liu, K. Igarashi, R. Sridharan, B. P. Tu, V. L. Cryns, D. W. Lamming, J. M. Denu
The paper shows that SAM depletion leads to adaptive chromatin changes that maintain heterochromatin stability and epigenetic persistence in mice.
bioRxiv · Sep 12, 2019Biochemistry