Author

L. C. Nguyen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Mohamed· 2 shared C. Dann· 2 shared D. Silva· 2 shared D. Yang· 2 shared G. Randall· 2 shared H. Gula· 2 shared M. R. Rosner· 2 shared N. Drayman· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

A. Mohamed

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Direct excitatory synapses between neurons and tumor cells drive brain metastatic seeding of breast cancer and melanoma

V. Venkataramani, M. A. Karreman, L. C. Nguyen, C. Tehranian, N. Hebach, C. Mayer, L. Meyer, S. Mughal, G. Reifenberger, J. Felsberg, K. Koehrer, M. C. Schubert, D. Westphal, M. Breckwolt, B. Brors, , F. Winkler

The paper shows neurons form direct excitatory synapses with brain-metastatic breast and melanoma cancer cells, supporting metastasis and offering new therapeutic targets.

bioRxiv · Jan 8, 2024 · PreprintCancer Biology

SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cells

L. C. Nguyen, D. M. Renner, D. Silva, D. Yang, N. Parenti, K. M. Medina, V. Nicolaescu, H. Gula, N. Drayman, A. Valdespino, A. Mohamed, C. Dann, K. Wannemo, L. Robinson-Mailman, A. Gonzalez, , S. R. Weiss

This study compares how SARS-CoV-2 and other betacoronaviruses activate the IRE1α/XBP1 ER stress pathway in human lung cells, finding that SARS-CoV-2 only partially activates it, potentially evading host immune detection.

bioRxiv · Dec 30, 2021 · PreprintMicrobiology

Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response

L. C. Nguyen, D. Yang, V. Nicolaescu, T. Best, S. Chen, J. B. Friesen, N. Drayman, A. Mohamed, C. Dann, D. Silva, H. Gula, K. A. Jones, J. M. Millis, B. C. Dickinson, S. Tay, , M. R. Rosner

This study shows that cannabidiol inhibits SARS-CoV-2 replication and enhances the host innate immune response in lung cells and human patients.

bioRxiv · Mar 10, 2021 · PreprintMicrobiology

Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence

S. A. Haws, D. Yu, C. Ye, C. K. Wille, L. C. Nguyen, K. A. Krautkramer, J. L. Tomasiewicz, S. E. Yang, B. R. Miller, W. H. Liu, K. Igarashi, R. Sridharan, B. P. Tu, V. L. Cryns, D. W. Lamming, J. M. Denu

The paper shows that SAM depletion leads to adaptive chromatin changes that maintain heterochromatin stability and epigenetic persistence in mice.

bioRxiv · Sep 12, 2019Biochemistry