Author

J. M. Denu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 2 Assay:metabolomics· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

S. A. Haws· 2 shared A. J. Lawton· 1 shared A. Mehendale· 1 shared B. P. Tu· 1 shared B. R. Miller· 1 shared C. Green· 1 shared C. K. Wille· 1 shared C. Ye· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiochemistry

S. A. Haws

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Author profile →

5 papers

Recent·Most cited

Individual dietary amino acid restrictions induce distinct metabolic and chromatin states

S. Haws, Y. Liu, C. Green, K. Chaiyakul, P. Mishra, R. Babygirija, E. Armstrong, A. Mehendale, I. M. Ong, D. Lamming, J. M. Denu

The paper investigates how dietary restriction of specific essential amino acids affects metabolism and chromatin states in mice, finding distinct effects for methionine, leucine, and isoleucine.

bioRxiv · Dec 6, 2023 · PreprintBiochemistry

Intrinsic catalytic properties of histone H3 lysine-9 methyltransferases preserve monomethylation levels under low S-adenosylmethionine

S. A. Haws, L. J. Miller, D. Rojas La Luz, V. Kuznetsov, R. C. Trievel, G. Craciun, J. M. Denu

This study shows H3K9 methyltransferases preferentially catalyze monomethylation, maintaining H3K9me1 levels during SAM depletion and recovery.

bioRxiv · Sep 9, 2022Biochemistry

Quantifying dynamic protein acetylation using quantitative stoichiometry

J. Baeza, A. J. Lawton, J. Fan, M. J. Smallegan, I. Leinert, T. Gandhi, O. M. Bernhardt, L. Reiter, J. M. Denu

The paper develops and validates a method to quantify acetylation stoichiometry, revealing dynamic changes in response to serum stimulation across cellular compartments and pathways.

bioRxiv · Feb 19, 2020Biochemistry

Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence

S. A. Haws, D. Yu, C. Ye, C. K. Wille, L. C. Nguyen, K. A. Krautkramer, J. L. Tomasiewicz, S. E. Yang, B. R. Miller, W. H. Liu, K. Igarashi, R. Sridharan, B. P. Tu, V. L. Cryns, D. W. Lamming, J. M. Denu

The paper shows that SAM depletion leads to adaptive chromatin changes that maintain heterochromatin stability and epigenetic persistence in mice.

bioRxiv · Sep 12, 2019Biochemistry

Bacterial analogs of plant piperidine alkaloids mediate microbial interactions in a rhizosphere model system

G. L. Lozano, H. B. Park, J. I. Bravo, E. A. Armstrong, J. M. Denu, E. V. Stabb, N. A. Broderick, J. M. Crawford, J. Handelsman

The paper identifies a novel family of bacterial piperidine alkaloids produced by Pseudomonas koreensis that mediate inter-bacterial competition in the rhizosphere, showing convergent evolution with plant alkaloids.

bioRxiv · Dec 19, 2018Microbiology