Author

C. Kalderen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

T. Helleday· 3 shared A. Egesten· 2 shared L. Tanner· 2 shared A. B. Single· 1 shared A. Hagenkort· 1 shared A. Stolz· 1 shared A.-S. Jemth· 1 shared C. Dong· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersPharmacology & Toxicology

T. Helleday

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3 papers

Recent·Most cited

OGG1 inhibitor TH5487 alleviates allergic airway inflammation in mice

L. Tanner, J. Bergwik, R. K. Bhongir, L. Pan, C. Dong, C. Kalderen, T. Helleday, I. Boldogh, M. Adner, A. Egesten

This study shows that TH5487, an OGG1 inhibitor, reduces allergic airway inflammation in mice by decreasing mucus production, immune cell recruitment, and proinflammatory cytokines.

bioRxiv · May 17, 2022 · PreprintPharmacology & Toxicology

Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis

L. Tanner, A. B. Single, R. K. V. Bonghir, R. Oomen, O. Wallner, T. Helleday, C. Kalderen, A. Egesten

This study shows that the small-molecule OGG1 inhibitor TH5487 reduces fibrosis and inflammation in a mouse model of pulmonary fibrosis.

bioRxiv · Feb 27, 2021 · PreprintPharmacology & Toxicology

MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells

H. Gad, O. Mortusewicz, S. G. Rudd, A. Stolz, N. Amaral, L. Brautigam, L. Pudelko, K. Sanjiv, C. Kalderen, A.-S. Jemth, I. Almlof, T. Visnes, N. Schultz, J. Bostrom, J. M. Calderon Montano, , T. Helleday

This study identifies MTH1's role in mitosis and shows that potent MTH1 inhibitors cause mitotic arrest by disrupting tubulin polymerization and suppressing ROS.

bioRxiv · Sep 5, 2019 · PreprintCancer Biology