GSDMD pore formation regulates caspase-4 cleavage to limit IL-18 production in the intestinal epithelium
J.K. Bruce, L. Li, Y. Tang, N. Winsor, C. Krustev, S. Keely, D. J. Philpott, S. E. Girardin
This study shows that GSDMD pore formation stops caspase-4 activity to control IL-18 production in intestinal epithelial cells, preventing excessive inflammation.
bioRxiv · Feb 1, 2024 · PreprintCell Biology