Author

J.K. Bruce

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Cell Biology· 1

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Krustev· 1 shared D. J. Philpott· 1 shared L. Li· 1 shared N. Winsor· 1 shared S. E. Girardin· 1 shared S. KeelyiD· 1 shared Y. Tang· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

C. Krustev

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1 paper

Recent·Most cited

GSDMD pore formation regulates caspase-4 cleavage to limit IL-18 production in the intestinal epithelium

J.K. Bruce, L. Li, Y. Tang, N. Winsor, C. Krustev, S. Keely, D. J. Philpott, S. E. Girardin

This study shows that GSDMD pore formation stops caspase-4 activity to control IL-18 production in intestinal epithelial cells, preventing excessive inflammation.

bioRxiv · Feb 1, 2024 · PreprintCell Biology