Simon Keely

This study identifies distinct duodenal microbiota and immune profiles in functional dyspepsia patients compared to controls, suggesting disrupted host-microbiome homeostasis.

The paper identifies a novel microbiota-derived protein, BMG-1, that inhibits neutrophil elastase and protects the intestinal barrier in IBD.

This study shows that antibiotic-induced microbiome modulation in mice alters immune responses to gluten, increasing duodenal eosinophils and activating epithelial γδ T-cells.

This paper identifies microbiome-derived therapeutics for IBD using a metagenome-guided approach, showing improved disease markers and safety in preclinical models.

This study shows that GSDMD pore formation stops caspase-4 activity to control IL-18 production in intestinal epithelial cells, preventing excessive inflammation.