Author

C. Leslie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. Akagbosu· 2 shared C. Brown· 2 shared G. Shibu· 2 shared T. Park· 2 shared A. Rudensky· 1 shared A. Y. Rudensky· 1 shared C. C. Brown· 1 shared C. Friedrich· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersImmunology

B. Akagbosu

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Thetis cells induce food-specific Treg cell differentiation and oral tolerance

Y. Parisotto, V. Cabric, T. Park, B. Akagbosu, Z. Zhao, Y. Lo, L. Fisher, G. Shibu, Y. Paucar Iza, C. Leslie, C. Brown

This study identifies Thetis cells IV as essential for food-specific Treg cell differentiation and oral tolerance, highlighting their distinct role from dendritic cells in immune regulation.

bioRxiv · May 8, 2024 · PreprintImmunology

Reconciling the spectrum of RORγt+ antigen-presenting cells

T. Park, C. Leslie, A. Rudensky, C. Brown

The paper reanalyzes single-cell RNA-seq data from three studies to reconcile discrepancies in identifying RORγt+ antigen-presenting cells and their role in pTreg induction.

bioRxiv · Nov 1, 2023 · PreprintImmunology

A novel RORγt+ antigen presenting cell type instructs microbiota-dependent regulatory T cell differentiation and tolerance during early life

B. Akagbosu, Z. Tayyebi, G. Shibu, Y. A. Paucar Iza, D. Deep, Y. Franco Parisotto, H. A. Pasolli, V. Thevin, R. Elmentaite, M. Knott, S. Hemmers, L. Jahn, C. Friedrich, J. Verter, Z. Wang, , C. C. Brown

This study identifies a new RORγt+ antigen-presenting cell type, Thetis cells, that drives microbiota-dependent regulatory T cell differentiation and tolerance during early life.

bioRxiv · Feb 26, 2022Immunology