Author

C. C. Brown

Primary ORCID profile (0009-0008-5213-5130 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

C. C. BrowniD1 paper · Imperial College London

Biology Disciplines

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

A. L. Croxford· 1 shared A. Lledo Lara· 1 shared A. Maroof· 1 shared A. Y. Rudensky· 1 shared B. Akagbosu· 1 shared C. Friedrich· 1 shared C. Guzzo· 1 shared C. Leslie· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

A. L. Croxford

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2 papers

Recent·Most cited

A novel RORγt+ antigen presenting cell type instructs microbiota-dependent regulatory T cell differentiation and tolerance during early life

B. Akagbosu, Z. Tayyebi, G. Shibu, Y. A. Paucar Iza, D. Deep, Y. Franco Parisotto, H. A. Pasolli, V. Thevin, R. Elmentaite, M. Knott, S. Hemmers, L. Jahn, C. Friedrich, J. Verter, Z. Wang, , C. C. Brown

This study identifies a new RORγt+ antigen-presenting cell type, Thetis cells, that drives microbiota-dependent regulatory T cell differentiation and tolerance during early life.

bioRxiv · Feb 26, 2022Immunology

Single-cell sequencing reveals a clonal expansion of pro-inflammatory synovial CD8 T cells expressing tissue homing receptors in psoriatic arthritis

F. Penkava, M. Del Castillo Velasco-Herrera, M. D. Young, N. Yager, A. Lledo Lara, C. Guzzo, A. Maroof, L. Mamanova, S. Cole, M. Efremova, D. Simone, C. C. Brown, A. L. Croxford, S. Teichmann, P. Bowness, , M. H. Al-Mossawi

The paper identifies clonal expansion of pro-inflammatory CD8 T cells in psoriatic arthritis joints using single-cell sequencing and links them to tissue homing receptors and antigen specificity.

bioRxiv · Jul 16, 2019Immunology