H. A. Pasolli

The Role of Ebola Virus VP24 Nuclear Trafficking Signals in Infectious Particle Production

This study demonstrates that Ebola virus VP24 undergoes nuclear trafficking via IMPA and its nuclear export signal (NES) is critical for nucleocapsid formation and infectivity.

A Window into Mammalian Basement Membrane Development: Insights from the mTurq2-Col4a1 Mouse Model

The paper introduces a mouse model with fluorescently labeled collagen IV to study basement membrane dynamics during skin development and finds that BMs deform rather than lose adhesion during cell division.

Stem cells tightly regulate dead cell clearance to maintain tissue fitness

The paper shows stem cells can temporarily act as phagocytes to clear dead cells, regulated by lipids and retinoids to maintain tissue health.

Cristae formation is a mechanical buckling event controlled by the inner membrane lipidome

The paper shows that cardiolipin buffers mitochondrial inner membrane curvature and ATP synthase organization, with a mathematical model predicting snapthrough instability in cristae formation.

Autolysosomal exocytosis of lipids protect neurons from ferroptosis

The paper shows that autolysosomal exocytosis of lipid-protein particles protects neurons from ferroptosis by removing peroxidated lipids and iron.

A tissue injury repair pathway distinct but parallel to host pathogen defense

This study identifies IL24 as a tissue repair pathway parallel to IFN-mediated host defense, showing its role in epithelial and mesenchymal regeneration after injury.

Motion of single molecular tethers reveals dynamic subdomains at ER-mitochondria contact sites

This study uses 3D electron microscopy and live cell imaging to reveal dynamic subdomains at ER-mitochondria contact sites and how VAPB tethers contribute to their structure and remodeling.

A novel RORγt+ antigen presenting cell type instructs microbiota-dependent regulatory T cell differentiation and tolerance during early life

This study identifies a new RORγt+ antigen-presenting cell type, Thetis cells, that drives microbiota-dependent regulatory T cell differentiation and tolerance during early life.

The integrated stress response remodels the microtubule organizing center to clear unfolded proteins following proteotoxic stress

This study shows that the integrated stress response (ISR) redirects translation to centrosomal proteins to clear unfolded proteins at the microtubule organizing center during proteotoxic stress in SCC stem cells.

A lymphatic-stem cell interactome regulates intestinal stem cell activity

The paper identifies lymphatic-secreted factors that maintain intestinal stem cells and inhibit their premature differentiation through a novel deconvolution algorithm and spatial transcriptomics.

An open-access volume electron microscopy atlas of whole cells and tissues

The paper presents a 3D electron microscopy atlas of whole cells and tissues with high resolution and large volume, enabling new biological insights.

A serotonergic axon-cilium synapse drives nuclear signaling to maintain chromatin accessibility

The paper identifies axo-ciliary synapses that mediate serotonin signaling to regulate chromatin accessibility in hippocampal neurons.

Correlative three-dimensional super-resolution and block face electron microscopy of whole vitreously frozen cells

This study develops a platform for 3D correlative cryogenic super-resolution and block-face EM of whole vitreously frozen cells, revealing new protein-ultrastructure relationships.

Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III

This study identifies Spastin's role in tethering lipid droplets to peroxisomes and facilitating fatty acid trafficking via ESCRT-III proteins.