Author

C. M. Arokiaraj

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Organism:rat· 2 Research Focus:cell-cell communication· 1 Organism:human· 1

Frequent Co-Authors

V. Gradinaru· 3 shared A. S. Fox· 2 shared D. A. Wolfe· 2 shared L. J. Campos· 2 shared M. R. Chuapoco· 2 shared T. F. Shay· 2 shared X. Chen· 2 shared X. Ding· 2 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersBioengineering

V. Gradinaru

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Author profile →

3 papers

Recent·Most cited

Human cell surface-AAV interactomes identify LRP6 as blood-brain-barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder

T. F. Shay, S. Jang, X. Chen, B. Walker, C. Tebbutt, D. A. Wolfe, T. J. Brittain, C. M. Arokiaraj, E. E. Sullivan, X. Ding, T.-Y. Wang, Y. Lei, M. R. Chuapoco, T.-F. Chou, V. Gradinaru

Nature Communications · Sep 8, 2024Peer-reviewedBioengineering

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates

X. Chen, D. A. Wolfe, D. Sivadasan Bindu, M. Zhang, N. Taskin, D. Goertsen, T. F. Shay, E. Sullivan, S. Ravindra Kumar, S.-F. Huang, C. M. Arokiaraj, V. Plattner, L. J. Campos, J. K. Mich, D. Monet, , V. Gradinaru

The paper develops AAV vectors with endothelial-specific tropism for brain delivery in rodents and broad tropism in primates, demonstrating their utility in genetic engineering of the blood-brain barrier.

bioRxiv · Jan 12, 2023Bioengineering

Intravenous gene transfer throughout the brain of infant Old World primates using AAV

M. R. Chuapoco, N. Flytzanis, N. Goeden, J. C. Octeau, K. M. Roxas, K. Y. Chan, J. Scherrer, J. Winchester, R. J. Blackburn, L. J. Campos, C. M. Arokiaraj, T. F. Miles, M. J. Jang, J. Vendemiatti, B. E. Deverman, , V. Gradinaru

This paper introduces AAV.CAP-Mac, an engineered AAV variant that enables efficient systemic brain-wide gene delivery in infant Old World primates.

bioRxiv · Jan 8, 2022Bioengineering