S. Jang

Human cell surface-AAV interactomes identify LRP6 as blood-brain-barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder

Long-term single-molecule tracking in living cells using weak-affinity protein labeling

This paper introduces a labeling method for long-term single-molecule tracking in living cells and demonstrates its application to study EGFR dynamics.

Structure of the human K2P13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site

This paper presents cryo-EM structures of human K2P13.1 (THIK-1) revealing a novel hydrophilic pore restriction and lipid cofactor site, with implications for modulator development.

Oligomeric HIV-1 Integrase Structures Reveal Functional Plasticity for Intasome Assembly and RNA Binding

This study determines cryo-EM structures of HIV-1 integrase tetramers and intasome hexadecamers, revealing structural plasticity and functional roles in viral integration and RNA binding.

Hundreds of antimicrobial peptides create a selective barrier for insect gut symbionts

The paper identifies hundreds of antimicrobial peptides in the insect gut that create a selective barrier for symbionts, with resistance mechanisms crucial for colonization.

An RNA interference (RNAi) toolkit and its utility for functional genetic analysis of Leishmania ( Viannia )

This study develops and applies RNAi tools to Leishmania (Viannia) species, showing that RNAi efficacy increases with stem length and enables hypomorphic analysis of essential genes.

Genome-scale CRISPR screening reveals host factors required for ribosome formation and viral replication

The paper identifies host factors required for ribosome formation and viral replication using CRISPR screening, showing that SPATA5 and SBDS are broadly needed for multiple virus types.

DBlink: Dynamic localization microscopy in super spatiotemporal resolution via deep learning

DBlink improves super spatiotemporal resolution in SMLM by using deep learning to reconstruct dynamic processes from video data.

PD1+ T-cells correlate with Nerve Fiber Density as a prognostic biomarker in patients with resected perihilar cholangiocarcinoma.

The paper investigates the association between PD1+ T-cells and nerve fiber density (NFD) in resected perihilar cholangiocarcinoma (pCCA) patients, finding that high NFD correlates with improved overall survival.

CSF-1 maintains pathogenic but not homeostatic myeloid cells in the central nervous system during autoimmune neuroinflammation.

This study shows that blocking CSF-1 reduces harmful myeloid cells in EAE without affecting beneficial ones, suggesting CSF-1 as a therapeutic target for MS.

A DNA-origami nuclear pore mimic reveals nuclear entry mechanisms of HIV-1 capsid

This study uses DNA-origami NPC mimics to show HIV-1 capsid uses a trimeric interface and RRR motif to pass through nuclear pores, bypassing the FG motif of NUP153.

Signature of N-terminal domain (NTD) structural re-orientation in NPC1 for proper alignment of cholesterol transport: Molecular dynamics study with mutation

This study uses molecular dynamics simulations to investigate how the R518W mutation in NPC1 affects its structure and cholesterol transport function, revealing a structural shift in the NTD that may impair NPC2 interaction.

Cytoplasmic CPSF6 regulates HIV-1 capsid trafficking and infection in a cyclophilin A-dependent manner

The paper shows CPSF6 and CypA interact to regulate HIV-1 capsid trafficking and infection by affecting capsid-CPSF6 complex formation and stability.

ThiL is a valid antibacterial target that is essential for both thiamine biosynthesis and salvage pathway in Pseudomonas aeruginosa

This study demonstrates that ThiL is essential for thiamine biosynthesis and salvage in Pseudomonas aeruginosa and identifies inhibitors with potential antibacterial activity.

Measuring three-dimensional dynamics of platelet activation using 3-D quantitative phase imaging

This paper uses 3-D quantitative phase imaging to study platelet activation dynamics, finding that thrombin and TRAP stimulation leads to lower cellular concentration and dry mass compared to resting platelets.

The Glycolytic Protein Phosphofructokinase Dynamically Relocalizes into Subcellular Compartments with Liquid-like Properties in vivo

This study shows that PFK-1.1 dynamically forms liquid-like condensates in neurons under energy stress, revealing a new mechanism for subcellular organization.

Structural basis of recognition and destabilization of histone H2B ubiquitinated nucleosome by DOT1L histone H3 Lys79 methyltransferase

The paper presents cryo-EM structures of DOT1L with nucleosomes and shows H2B ubiquitination enhances DOT1L's non-catalytic nucleosome destabilization function.

Refractive index tomograms and dynamic membrane fluctuations of red blood cells from patients with diabetes mellitus

This study uses 3-D quantitative phase imaging to analyze morphological, biochemical, and mechanical properties of red blood cells from diabetic and non-diabetic patients, finding reduced sphericity, higher haemoglobin content, and lower membrane deformability in diabetic RBCs.