Author

T. F. Shay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

V. Gradinaru· 4 shared X. Chen· 4 shared X. Ding· 4 shared E. E. Sullivan· 3 shared C. M. Arokiaraj· 2 shared D. A. Wolfe· 2 shared D. Goertsen· 2 shared A. Akrami· 1 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersBioengineering

V. Gradinaru

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Author profile →

4 papers

Recent·Most cited

Human cell surface-AAV interactomes identify LRP6 as blood-brain-barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder

T. F. Shay, S. Jang, X. Chen, B. Walker, C. Tebbutt, D. A. Wolfe, T. J. Brittain, C. M. Arokiaraj, E. E. Sullivan, X. Ding, T.-Y. Wang, Y. Lei, M. R. Chuapoco, T.-F. Chou, V. Gradinaru

Nature Communications · Sep 8, 2024Peer-reviewedBioengineering

Primate-conserved Carbonic Anhydrase IV and murine-restricted Ly6c1 are new targets for crossing the blood-brain barrier

T. F. Shay, E. E. Sullivan, X. Ding, X. Chen, S. R. Kumar, D. Goertsen, D. Brown, J. Vielmetter, M. Borsos, A. W. Lam, V. Gradinaru

The paper identifies two new receptors, Ly6c1 and Car4/CA4, for crossing the blood-brain barrier using AAV vectors and computational modeling.

bioRxiv · Jan 12, 2023Bioengineering

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates

X. Chen, D. A. Wolfe, D. Sivadasan Bindu, M. Zhang, N. Taskin, D. Goertsen, T. F. Shay, E. Sullivan, S. Ravindra Kumar, S.-F. Huang, C. M. Arokiaraj, V. Plattner, L. J. Campos, J. K. Mich, D. Monet, , V. Gradinaru

The paper develops AAV vectors with endothelial-specific tropism for brain delivery in rodents and broad tropism in primates, demonstrating their utility in genetic engineering of the blood-brain barrier.

bioRxiv · Jan 12, 2023Bioengineering

Fast, accurate ranking of engineered proteins by receptor binding propensity using structure modeling

X. Ding, X. Chen, E. E. Sullivan, T. F. Shay, V. Gradinaru

This paper introduces APPRAISE, a method that rapidly ranks engineered proteins by their receptor binding propensity using structure modeling, demonstrating its accuracy on various protein classes.

bioRxiv · Jan 11, 2023Bioengineering