T.-F. Chou

Allele-selective knockdown of mutant DNAJB6 improves molecular features in a primary mouse myotube model of LGMDD1

This study uses allele-selective knockdown to reduce mutant DNAJB6 in a mouse model of LGMDD1, improving molecular features associated with the disease.

Internal regulation between constitutively expressed T cell coinhibitory receptors BTLA and CD5 and tolerance in recent thymic emigrants

This study identifies a regulatory pathway between BTLA and CD5 in T cells that calibrates their expression to establish self-tolerance in recent thymic emigrants.

Human cell surface-AAV interactomes identify LRP6 as blood-brain-barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder

Single tissue proteomics in Caenorhabditis elegans reveals proteins resident in intestinal lysosome-related organelles

The paper uses single-tissue proteomics in C. elegans to identify proteins in intestinal lysosome-related organelles, revealing novel components and interorgan protein transport.

Unexplored regions of the protein sequence-structure map revealed at scale by a library of foldtuned language models

This paper introduces foldtuning, a method to generate novel protein sequences with target structures, bypassing evolutionary barriers and enabling synthetic biology applications.

Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins

The paper studies the biogenesis of ER membrane proteins, identifying the EMC and BOS complex as key players and proposing a model for coordinated insertion.

Staphylococcal secreted cytotoxins are competition sensing signals for Pseudomonas aeruginosa

This study shows Pseudomonas aeruginosa uses Staphylococcus aureus secreted toxins as signals to detect competition and activate its type six secretion system to outcompete S. aureus during coinfection.

MTCH2 is a mitochondrial outer membrane protein insertase

The paper identifies MTCH2 as an insertase required for mitochondrial TA protein insertion and shows its role in controlling TA localization and apoptosis sensitivity.

HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160

The paper determines HVEM structures and generates mutants to reveal distinct functions of binding to LIGHT and BTLA/CD160 in immune responses.

The globular C1q receptor is required for epidermal growth factor receptor signaling during Candida albicans infection

This study identifies proteins interacting with EGFR during C. albicans infection and shows that gC1qR is essential for EGFR signaling and immune responses.