Author

K. Y. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

V. Gradinaru· 2 shared A. Moradian· 1 shared A. S. Fox· 1 shared B. B. Yoo· 1 shared B. Chen· 1 shared B. E. Deverman· 1 shared C. Challis· 1 shared C. M. Arokiaraj· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBioengineering

V. Gradinaru

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Author profile →

3 papers

Recent·Most cited

Clearance of protein aggregates during cell division

S. Du, Y. Wang, B. Chen, S. Xie, K. Y. Chan, D. C. Hay, T. G. Chew

The paper investigates how protein aggregates are cleared during cell division, finding that ER reorganization and BiP-mediated clearance occur during mitosis and cytokinesis.

bioRxiv · Feb 10, 2024Cell Biology

Intravenous gene transfer throughout the brain of infant Old World primates using AAV

M. R. Chuapoco, N. Flytzanis, N. Goeden, J. C. Octeau, K. M. Roxas, K. Y. Chan, J. Scherrer, J. Winchester, R. J. Blackburn, L. J. Campos, C. M. Arokiaraj, T. F. Miles, M. J. Jang, J. Vendemiatti, B. E. Deverman, , V. Gradinaru

This paper introduces AAV.CAP-Mac, an engineered AAV variant that enables efficient systemic brain-wide gene delivery in infant Old World primates.

bioRxiv · Jan 8, 2022Bioengineering

Peripheral Neuronal Activation Shapes the Microbiome and Alters Gut Physiology

J. A. Griffiths, B. B. Yoo, P. Thuy-Boun, V. Cantu, K. Weldon, C. Challis, M. J. Sweredoski, K. Y. Chan, T. M. Thron, G. Sharon, A. Moradian, G. Humphrey, Q. Zhu, J. Shaffer, D. W. Wolan, , S. Mazmanian

This study activates specific gut neurons in mice to show they influence microbiome structure and gut physiology, including bile acids and fecal output, without brain signals.

bioRxiv · Apr 12, 2021Physiology