Evaluation of IL-1 blockade as an adjunct to linezolid therapy for tuberculosis in mice and macaques
C. G. M. Winchell, B. B. Mishra, J. Y. Phuah, M. Saqib, S. J. Nelson, P. Maiello, C. M. Causgrove, C. L. Ameel, B. Stein, H. J. Borish, A. G. White, E. C. Klein, M. D. Zimmerman, V. Dartois, P. L. Lin, , J. L. Flynn
This study evaluates IL-1 blockade as an adjunct to linezolid therapy for tuberculosis in mice and macaques, finding reduced inflammation and preserved host response without impairing treatment efficacy.
Frontiers in Immunology · May 12, 2020Peer-reviewedMicrobiology