Author

M. Saqib

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Physiology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

B. B. Mishra· 3 shared A. K. Ojha· 2 shared D. C. Sarver· 2 shared G. W. Wong· 2 shared P. Sankar· 2 shared Y. Cai· 2 shared A. G. White· 1 shared B. Stein· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersImmunology

B. B. Mishra

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Loss of CTRP10 results in female obesity with preserved metabolic health

F. Chen, D. C. Sarver, M. Saqib, L. M. Velez, S. Aja, M. M. Seldin, G. W. Wong

This study shows that loss of CTRP10 in female mice leads to obesity without metabolic complications, highlighting a sex-dependent role in metabolic health.

bioRxiv · Nov 1, 2023Physiology

Fatty acid metabolism in neutrophils promotes lung damage and bacterial replication during tuberculosis.

B. B. Mishra, P. Sankar, R. B. Ramos, J. Corro, M. Saqib, T. N. Nafiz, G. Bhargavi, A. K. Ojha, Y. Cai, S. Subbian

This study shows that fatty acid metabolism in neutrophils worsens lung damage and bacterial replication in tuberculosis by promoting inflammation and neutrophil recruitment.

bioRxiv · Oct 25, 2023Immunology

Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition

D. C. Sarver, J. Garcia-Diaz, M. Saqib, R. C. Riddle, G. W. Wong

This study shows that Tmem263 deletion in mice causes dwarfism and skeletal issues by disrupting the GH/IGF-1 axis, linking TMEM263 to growth regulation.

bioRxiv · Aug 2, 2023Physiology

Neutrophils reprograms the bone marrow to impair T-cell immunity during tuberculosis

M. Saqib, E. McDonough, S. Das, Z. Cheng, P. Sankar, F. Li, Q. Yang, Y. Xu, W. Wang, X. Chen, A. K. Ojha, F. Ginty, Y. Cai, B. B. Mishra

This study shows that neutrophils in tuberculosis promote pathologic hematopoiesis by producing G-CSF, which impairs T-cell immunity through IFNAR1 signaling.

bioRxiv · Jun 28, 2022 · PreprintImmunology

Evaluation of IL-1 blockade as an adjunct to linezolid therapy for tuberculosis in mice and macaques

C. G. M. Winchell, B. B. Mishra, J. Y. Phuah, M. Saqib, S. J. Nelson, P. Maiello, C. M. Causgrove, C. L. Ameel, B. Stein, H. J. Borish, A. G. White, E. C. Klein, M. D. Zimmerman, V. Dartois, P. L. Lin, , J. L. Flynn

This study evaluates IL-1 blockade as an adjunct to linezolid therapy for tuberculosis in mice and macaques, finding reduced inflammation and preserved host response without impairing treatment efficacy.

Frontiers in Immunology · May 12, 2020Peer-reviewedMicrobiology