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Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
16 papers
Recent·Most cited
J. Bromley, S. K. C. Ganchua, S. K. Nyquist, P. Maiello, M. Chao, H. J. Borish, M. Rodgers, J. Tomko, K. Kracinovsky, D. Mugahid, S. N. Nguyen, D. Wang, J. M. Rosenberg, E. C. Klein, H. P. Gideon, , J. L. Flynn
The paper shows that CD4+ T cells reduce inflammation and disease severity during Mtb reinfection by reprogramming CD8+ T cells and innate immune cells.
bioRxiv · Dec 20, 2023 · PreprintImmunology
S. K. Ganchua, P. Maiello, M. Chao, F. Hopkins, D. Mugahid, P. L. Lin, S. M. Fortune, J. L. Flynn
This study shows antibiotic treatment after primary Mtb infection reduces lung inflammation but does not eliminate protection against reinfection in macaques.
bioRxiv · Dec 19, 2023Microbiology
A. A. Smith, H. Su, J. Wallach, Y. Liu, P. Maiello, H. J. Borish, C. Winchell, A. W. Simonson, P. L. Lin, M. Rodgers, D. J. Filmore, J. Sakal, K. Lin, V. Vinette, D. Schnappinger, , J. L. Flynn
This study develops a 'suicide' BCG strain that is safely eliminated in immunocompromised hosts but induces stronger immune responses and better protection against Mtb in macaques.
bioRxiv · Nov 22, 2023 · PreprintImmunology
M. Budak, J. M. Cicchese, P. Maiello, H. J. Borish, A. G. White, H. B. Chishti, J. Tomko, L. J. Frye, D. Fillmore, K. Kracinovsky, J. Sakal, C. A. Scanga, P. L. Lin, V. Dartois, J. J. Linderman, , D. E. Kirschner
This study compares standard TB treatment with moxifloxacin-containing regimens using computational models and experimental validation to identify more effective and patient-friendly treatment options.
bioRxiv · Dec 18, 2022Pharmacology & Toxicology
E. C. Larson, A. L. Ellis-Connell, M. Rodgers, A. K. Gubernat, J. L. Gleim, R. V. Moriarty, A. J. Balgeman, Y. K. Menezes, C. Ameel, D. J. Filmore, S. M. Pergalske, J. A. Juno, P. Maiello, A. G. White, H. J. Borish, , C. A. Scanga
This study compares host immunity to Mycobacterium tuberculosis in SIV-infected, ART-treated and SIV-naïve juvenile macaques, finding similar TB progression and T cell responses.
bioRxiv · Dec 14, 2022 · PreprintImmunology
N. L. Grant, K. Kelly, P. Maiello, H. Abbott, S. L. O'Connor, P. L. Lin, C. A. Scanga, J. L. Flynn
The paper identifies Mtb-specific CD4 T cells in granulomas and shows that transcription factors T-bet and RORγT correlate with bacterial control.
bioRxiv · Nov 30, 2022 · PreprintImmunology
Y. E. Liu, P. A. Darrah, J. J. Zeppa, M. Kamath, F. Laboune, D. C. Doueck, P. Maiello, M. Roederer, J. L. Flynn, R. A. Seder, P. Khatri
The paper identifies blood transcriptional signatures from BCG-vaccinated rhesus macaques that correlate with protection against tuberculosis.
bioRxiv · Nov 14, 2022Immunology
N. L. Grant, P. Maiello, E. Klein, P. L. Lin, H. J. Borish, J. Tomko, L. J. Frye, A. G. White, D. E. Kirschner, J. T. Mattila, J. L. Flynn
This study tracks T cell transcription factor expression in granulomas of Mtb-infected macaques over time, showing increased T-bet+ T cells correlate with reduced bacterial burden.
bioRxiv · Jan 25, 2022 · PreprintImmunology
R. V. Moriarty, M. Rodgers, A. Ellis-Connell, A. J. Balgeman, E. C. Larson, F. Hopkins, M. R. Chase, P. Maiello, S. Fortune, C. A. Scanga, S. L. O'Connor
This study shows that SIV+ animals, regardless of viral control, have higher Mtb burden and dysregulated immune responses, leading to increased bacterial dissemination.
bioRxiv · May 10, 2021 · PreprintMicrobiology
E. Larson, A. L. Ellis, M. A. Rodgers, A. J. Balgeman, R. V. Moriarty, C. Ameel, T. Baranowski, J. Tomko, C. Causgrove, P. Maiello, S. L. OConnor, C. A. Scanga
This study shows that pre-existing SIV infection alters T cell phenotypes and reduces TNF responses during early Mtb co-infection, impairing immune control.
bioRxiv · Dec 14, 2020Immunology
H. P. Gideon, T. K. Hughes, C. N. Tzouanas, M. H. Wadsworth, A. A. Tu, T. M. Gierahn, J. M. Peters, F. H. Hopkins, J.-R. Wei, C. Kummerlowe, N. L. Grant, K. Nargan, J. Phuah, H. J. Borish, P. Maiello, , A. K. Shalek
The paper identifies cellular and temporal factors associated with bacterial control in tuberculosis granulomas using multimodal data.
bioRxiv · Oct 24, 2020 · PreprintImmunology
C. G. M. Winchell, B. B. Mishra, J. Y. Phuah, M. Saqib, S. J. Nelson, P. Maiello, C. M. Causgrove, C. L. Ameel, B. Stein, H. J. Borish, A. G. White, E. C. Klein, M. D. Zimmerman, V. Dartois, P. L. Lin, , J. L. Flynn
This study evaluates IL-1 blockade as an adjunct to linezolid therapy for tuberculosis in mice and macaques, finding reduced inflammation and preserved host response without impairing treatment efficacy.
Frontiers in Immunology · May 12, 2020Peer-reviewedMicrobiology
C. R. Diedrich, T. Rutledge, P. Maiello, T. M. Baranowski, A. G. White, H. J. Borish, P. Karell, F. Hopkins, J. Brown, S. M. Fortune, J. L. Flynn, Z. Ambrose, P. L. Lin
This study compares the effects of SIV infection and CD4 depletion on Mtb reactivation in a macaque model, finding that SIV promotes more severe granuloma dissemination and bacterial burden.
bioRxiv · Feb 21, 2020Immunology
A. L. Ellis, A. J. Balgeman, E. C. Larson, M. Rodgers, C. Ameel, T. Baranowski, P. Maiello, J. Juno, C. Scanga, S. L. O'Connor
This study examines MAIT cell function in a macaque model of SIV and Mtb co-infection, finding minimal Mtb responsiveness within granulomas and impaired TNF secretion during co-infection.
bioRxiv · Jan 7, 2020 · PreprintImmunology
J. L. Flynn, A. M. Cadena, F. H. Hopkins, P. Maiello, A. F. Carey, E. A. Wong, C. J. Martin, H. P. Gideon, R. M. DiFazio, P. Andersen, P. L. Lin, S. M. Fortune
This study shows that concurrent M. tuberculosis infection in macaques provides strong protection against secondary infection.
bioRxiv · Aug 29, 2018Microbiology
M. Rodgers, C. Ameel, A. Ellis-Connell, A. Balgeman, P. Maiello, G. Barry, T. Friedrich, E. Klein, S. O'Connor, C. Scanga
This study shows that pre-existing SIV infection in macaques increases susceptibility to tuberculosis by impairing immune control of M.tb.
bioRxiv · Jul 3, 2018Immunology