J. L. Flynn

Distributable, Metabolic PET Reporting of Tuberculosis

This paper introduces [18F]FDT, a PET tracer that specifically images Mycobacterium tuberculosis lesions and monitors treatment, enabling global access through a simple synthesis method from [18F]FDG.

CD4+ T cells are homeostatic regulators during Mtb reinfection

The paper shows that CD4+ T cells reduce inflammation and disease severity during Mtb reinfection by reprogramming CD8+ T cells and innate immune cells.

Antibiotic treatment does not abrogate protection against Mycobacterium tuberculosis reinfection

This study shows antibiotic treatment after primary Mtb infection reduces lung inflammation but does not eliminate protection against reinfection in macaques.

A "suicide" BCG strain provides enhanced immunogenicity and robust protection against Mycobacterium tuberculosis in macaques

This study develops a 'suicide' BCG strain that is safely eliminated in immunocompromised hosts but induces stronger immune responses and better protection against Mtb in macaques.

Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model

This paper develops an engineered Mycobacterium tuberculosis strain with kill switches for a safe TB human challenge model, showing rapid clearance and low escape rates.

Humoral correlates of protection against Mycobacterium tuberculosis following intravenous Bacille Calmette-Guerin vaccination in rhesus macaques

This study identifies humoral immune responses as correlates of protection against Mtb following IV BCG vaccination in rhesus macaques.

Protective intravenous BCG vaccination induces enhanced immune signaling in the airways

This study shows that high-dose IV BCG vaccination in rhesus macaques enhances airway immune signaling and cellular responses, improving protection against Mtb.

Optimizing tuberculosis treatment efficacy: comparing the standard regimen with Moxifloxacin-containing regimens

This study compares standard TB treatment with moxifloxacin-containing regimens using computational models and experimental validation to identify more effective and patient-friendly treatment options.

Mycobacterium tuberculosis-specific CD4 T cells expressing transcription factors associate with bacterial control in granulomas

The paper identifies Mtb-specific CD4 T cells in granulomas and shows that transcription factors T-bet and RORγT correlate with bacterial control.

Blood Transcriptional Correlates of BCG-Induced Protection Against Tuberculosis in Rhesus Macaques

The paper identifies blood transcriptional signatures from BCG-vaccinated rhesus macaques that correlate with protection against tuberculosis.

Concomitant immunity to M. tuberculosis infection

This study uses a virtual host model to predict that concomitant immunity against M. tuberculosis is linked to tissue-resident memory T cells, with an estimated lifespan of 2-3 years in human lung tissue.

T cell transcription factor expression evolves as adaptive immunity matures in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques

This study tracks T cell transcription factor expression in granulomas of Mtb-infected macaques over time, showing increased T-bet+ T cells correlate with reduced bacterial burden.

Robust IgM responses following vaccination are associated with prevention of Mycobacterium tuberculosis infection in macaques

This study shows that IV BCG vaccination in macaques induces strong IgM responses associated with reduced Mtb bacterial burden and protection.

Multimodal profiling of lung granulomas reveals cellular correlates of tuberculosis control

The paper identifies cellular and temporal factors associated with bacterial control in tuberculosis granulomas using multimodal data.

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and prolonged shedding of infectious virus from both respiratory and gastrointestinal tracts

Evaluation of IL-1 blockade as an adjunct to linezolid therapy for tuberculosis in mice and macaques

This study evaluates IL-1 blockade as an adjunct to linezolid therapy for tuberculosis in mice and macaques, finding reduced inflammation and preserved host response without impairing treatment efficacy.

SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis

This study compares the effects of SIV infection and CD4 depletion on Mtb reactivation in a macaque model, finding that SIV promotes more severe granuloma dissemination and bacterial burden.

A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination

This paper develops a computational model to simulate Mtb infection in lungs and identifies factors that prevent bacterial dissemination.

Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques

This study shows that concurrent M. tuberculosis infection in macaques provides strong protection against secondary infection.