Author

H. J. Borish

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:non-human primate· 8 Research Focus:host-pathogen & immune response· 7 Approach:experimental assay· 6 Approach:deep learning· 3 Research Focus:drug response / drug discovery· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Assay:clinical cohort / trial· 2

Frequent Co-Authors

J. L. Flynn· 8 shared P. Maiello· 8 shared P. L. Lin· 7 shared A. G. White· 6 shared D. E. Kirschner· 3 shared H. P. Gideon· 3 shared J. Tomko· 3 shared L. J. Frye· 3 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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8 shared papersImmunology

J. L. Flynn

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

CD4+ T cells are homeostatic regulators during Mtb reinfection

J. Bromley, S. K. C. Ganchua, S. K. Nyquist, P. Maiello, M. Chao, H. J. Borish, M. Rodgers, J. Tomko, K. Kracinovsky, D. Mugahid, S. N. Nguyen, D. Wang, J. M. Rosenberg, E. C. Klein, H. P. Gideon, , J. L. Flynn

The paper shows that CD4+ T cells reduce inflammation and disease severity during Mtb reinfection by reprogramming CD8+ T cells and innate immune cells.

bioRxiv · Dec 20, 2023 · PreprintImmunology

A "suicide" BCG strain provides enhanced immunogenicity and robust protection against Mycobacterium tuberculosis in macaques

A. A. Smith, H. Su, J. Wallach, Y. Liu, P. Maiello, H. J. Borish, C. Winchell, A. W. Simonson, P. L. Lin, M. Rodgers, D. J. Filmore, J. Sakal, K. Lin, V. Vinette, D. Schnappinger, , J. L. Flynn

This study develops a 'suicide' BCG strain that is safely eliminated in immunocompromised hosts but induces stronger immune responses and better protection against Mtb in macaques.

bioRxiv · Nov 22, 2023 · PreprintImmunology

Optimizing tuberculosis treatment efficacy: comparing the standard regimen with Moxifloxacin-containing regimens

M. Budak, J. M. Cicchese, P. Maiello, H. J. Borish, A. G. White, H. B. Chishti, J. Tomko, L. J. Frye, D. Fillmore, K. Kracinovsky, J. Sakal, C. A. Scanga, P. L. Lin, V. Dartois, J. J. Linderman, , D. E. Kirschner

This study compares standard TB treatment with moxifloxacin-containing regimens using computational models and experimental validation to identify more effective and patient-friendly treatment options.

bioRxiv · Dec 18, 2022Pharmacology & Toxicology

Host Immunity to Mycobacterium tuberculosis Infection is Similar in Simian Immunodeficiency Virus (SIV)-infected, Antiretroviral Therapy-treated and SIV-naïve Juvenile Macaques

E. C. Larson, A. L. Ellis-Connell, M. Rodgers, A. K. Gubernat, J. L. Gleim, R. V. Moriarty, A. J. Balgeman, Y. K. Menezes, C. Ameel, D. J. Filmore, S. M. Pergalske, J. A. Juno, P. Maiello, A. G. White, H. J. Borish, , C. A. Scanga

This study compares host immunity to Mycobacterium tuberculosis in SIV-infected, ART-treated and SIV-naïve juvenile macaques, finding similar TB progression and T cell responses.

bioRxiv · Dec 14, 2022 · PreprintImmunology

T cell transcription factor expression evolves as adaptive immunity matures in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques

N. L. Grant, P. Maiello, E. Klein, P. L. Lin, H. J. Borish, J. Tomko, L. J. Frye, A. G. White, D. E. Kirschner, J. T. Mattila, J. L. Flynn

This study tracks T cell transcription factor expression in granulomas of Mtb-infected macaques over time, showing increased T-bet+ T cells correlate with reduced bacterial burden.

bioRxiv · Jan 25, 2022 · PreprintImmunology

Multimodal profiling of lung granulomas reveals cellular correlates of tuberculosis control

H. P. Gideon, T. K. Hughes, C. N. Tzouanas, M. H. Wadsworth, A. A. Tu, T. M. Gierahn, J. M. Peters, F. H. Hopkins, J.-R. Wei, C. Kummerlowe, N. L. Grant, K. Nargan, J. Phuah, H. J. Borish, P. Maiello, , A. K. Shalek

The paper identifies cellular and temporal factors associated with bacterial control in tuberculosis granulomas using multimodal data.

bioRxiv · Oct 24, 2020 · PreprintImmunology

Evaluation of IL-1 blockade as an adjunct to linezolid therapy for tuberculosis in mice and macaques

C. G. M. Winchell, B. B. Mishra, J. Y. Phuah, M. Saqib, S. J. Nelson, P. Maiello, C. M. Causgrove, C. L. Ameel, B. Stein, H. J. Borish, A. G. White, E. C. Klein, M. D. Zimmerman, V. Dartois, P. L. Lin, , J. L. Flynn

This study evaluates IL-1 blockade as an adjunct to linezolid therapy for tuberculosis in mice and macaques, finding reduced inflammation and preserved host response without impairing treatment efficacy.

Frontiers in Immunology · May 12, 2020Peer-reviewedMicrobiology

SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis

C. R. Diedrich, T. Rutledge, P. Maiello, T. M. Baranowski, A. G. White, H. J. Borish, P. Karell, F. Hopkins, J. Brown, S. M. Fortune, J. L. Flynn, Z. Ambrose, P. L. Lin

This study compares the effects of SIV infection and CD4 depletion on Mtb reactivation in a macaque model, finding that SIV promotes more severe granuloma dissemination and bacterial burden.

bioRxiv · Feb 21, 2020Immunology

A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination

T. Wessler, L. R. Joslyn, H. J. Borish, H. P. Gideon, J. L. Flynn, D. E. Kirschner, J. J. Linderman

This paper develops a computational model to simulate Mtb infection in lungs and identifies factors that prevent bacterial dissemination.

bioRxiv · Jul 24, 2019Immunology