Author

C. M. Hoel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein structure prediction· 4 Assay:cryo-EM· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

S. G. Brohawn· 4 shared A. Kotecha· 1 shared B. Al-Shayeb· 1 shared B. Li· 1 shared B. Sorum· 1 shared D. B. Toso· 1 shared D. M. Bautista· 1 shared D. M. Kern· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersBiophysics

S. G. Brohawn

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4 papers

Recent·Most cited

BiophysicsbioRxivJun 20, 2022

Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A

C. M. Hoel, L. Zhang, S. G. Brohawn

This study determines the cryo-EM structure of TMEM87A, revealing its domain arrangement and suggesting a role in membrane trafficking rather than ion channel or GPCR function.

DOI 10.7554/elife.81704

humancryo-EM

𝕏 PostBluesky

BiochemistrybioRxivAug 15, 2021

Structures of Tweety Homolog Proteins TTYH2 and TTYH3 reveal a Ca2+-dependent switch from intra- to inter-membrane dimerization

B. Li, C. M. Hoel, S. G. Brohawn

The paper determines cryo-EM structures of TTYH2 and TTYH3, revealing Ca2+-dependent shifts in dimerization mode and absence of ion channel activity.

DOI 10.1038/s41467-021-27283-8

mousecryo-EM

𝕏 PostBluesky

BiophysicsNature Structural & Molecular BiologyPeer-reviewedJun 22, 2021

Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs

D. M. Kern, B. Sorum, S. S. Mali…·S. G. Brohawn

This study presents the cryo-EM structure of SARS-CoV-2 3a ion channel in lipid nanodiscs, revealing its functional properties and evolutionary conservation.

DOI 10.1038/s41594-021-00619-0

viruscryo-EM

𝕏 PostBluesky

BiochemistrybioRxivOct 18, 2020

Structural coordination between active sites of a Cas6-reverse transcriptase-Cas1--Cas2 CRISPR integrase complex

J. Y. Wang, C. M. Hoel, B. Al-Shayeb…·J. A. Doudna

The paper determines the cryo-EM structure of a Cas6-RT-Cas1-Cas2 complex and shows bidirectional and unidirectional crosstalk between its active sites.

DOI 10.1038/s41467-021-22900-y

structural biologyexperimental assay

𝕏 PostBluesky