S. G. Brohawn

This study investigates how TRAAK K+ channels respond to mechanical tension and ultrasound, showing high sensitivity and a graded response profile.

This study determines the structure of LRRC8A:C channels and shows how lipid interactions regulate their gating and assembly.

This study determines the cryo-EM structure of TMEM87A, revealing its domain arrangement and suggesting a role in membrane trafficking rather than ion channel or GPCR function.

The paper presents the cryo-EM structure of SARS-CoV-2 M protein in lipid nanodiscs, revealing its homodimer structure and potential role in viral assembly.

This study identifies small molecule modulators of the SWELL1-LRRC8 complex that improve glycemic control and prevent NAFLD in murine T2D by restoring insulin signaling and secretion.

The paper determines cryo-EM structures of TTYH2 and TTYH3, revealing Ca2+-dependent shifts in dimerization mode and absence of ion channel activity.

This study presents the cryo-EM structure of SARS-CoV-2 3a ion channel in lipid nanodiscs, revealing its functional properties and evolutionary conservation.

This study identifies structural and functional differences between basal and mechanically-gated activity in the TRAAK K+ channel, explaining how a single channel can produce distinct modes of activity.

The paper determines the cryo-EM structure of a Cas6-RT-Cas1-Cas2 complex and shows bidirectional and unidirectional crosstalk between its active sites.

The paper presents the cryo-EM structure of KCC4, revealing its architecture, substrate binding sites, and transport mechanism.