Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
D. M. Kern, J. Bleier, S. Mukherjee, J. M. Hill, A. A. Kossiakoff, E. Y. Isacoff, S. G. Brohawn
This study determines the structure of LRRC8A:C channels and shows how lipid interactions regulate their gating and assembly.
bioRxiv · Jul 31, 2022Biophysics
K. A. Dolan, M. Dutta, D. M. Kern, A. Kotecha, G. A. Voth, S. G. Brohawn
The paper presents the cryo-EM structure of SARS-CoV-2 M protein in lipid nanodiscs, revealing its homodimer structure and potential role in viral assembly.
bioRxiv · Jun 12, 2022Biophysics
S. K. Gunasekar, L. Xie, P. R. Chheda, C. Kang, D. M. Kern, C. My-Ta, A. Kumar, J. M. Maurer, E. E. Gerber, W. J. Grzesik, M. Elliot-Hudson, Y. Zhang, C. A. Kulkarni, I. Samuel, J. K. Smith, , R. Sah
This study identifies small molecule modulators of the SWELL1-LRRC8 complex that improve glycemic control and prevent NAFLD in murine T2D by restoring insulin signaling and secretion.
Nature Communications · Feb 10, 2022Peer-reviewedPhysiology
D. M. Kern, B. Sorum, S. S. Mali, C. M. Hoel, S. Sridharan, J. P. Remis, D. B. Toso, A. Kotecha, D. M. Bautista, S. G. Brohawn
This study presents the cryo-EM structure of SARS-CoV-2 3a ion channel in lipid nanodiscs, revealing its functional properties and evolutionary conservation.
Nature Structural & Molecular Biology · Jun 22, 2021Peer-reviewedBiophysics