Author

B. T. McCune

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. K. Pfeiffer· 2 shared M. S. Diamond· 2 shared A. L. Bailey· 1 shared A. M. Peters· 1 shared A. O. Hassan· 1 shared A. S. Kim· 1 shared A. Schaefer· 1 shared A. W. Wessel· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

J. K. Pfeiffer

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6 papers

Recent·Most cited

Interferons and tuft cell numbers are bottlenecks for persistent murine norovirus infection

S. Aggarwal, F. C. Walker, J. S. Weagley, B. T. McCune, X. Wu, L. Schreifer, H. Makimaa, D. Lawrence, P. Sridhar, M. T. Baldridge

This study uses barcoded viruses to show that IFN-λ and tuft cell numbers limit persistent murine norovirus infection, with distinct viral populations in intestinal and extraintestinal sites.

bioRxiv · Feb 22, 2024Microbiology

A single intranasal dose of chimpanzee adenovirus-vectored vaccine confers sterilizing immunity against SARS-CoV-2 infection

A. O. Hassan, N. M. Kafai, I. P. Dmitriev, J. M. Fox, B. Smith, I. B. Harvey, R. E. Chen, E. S. Winkler, A. W. Wessel, J. B. Case, E. Kashentseva, B. T. McCune, A. L. Bailey, H. Zhao, L. A. VanBlargan, , M. S. Diamond

A single intranasal dose of ChAd-SARS-CoV-2-S vaccine prevents SARS-CoV-2 infection and likely confers sterilizing immunity in mice.

bioRxiv · Jul 16, 2020 · PreprintMicrobiology

TMPRSS2 and TMPRSS4 mediate SARS-CoV-2 infection of human small intestinal enterocytes

R. Zang, M. F. G. Castro, B. T. McCune, Q. Zeng, P. W. Rothlauf, N. M. Sonnek, Z. Liu, K. F. Brulois, X. Wang, H. B. Greenberg, M. S. Diamond, M. A. Ciorba, S. P. J. Whelan, S. Ding

This study shows SARS-CoV-2 infects human intestinal enterocytes via TMPRSS2 and TMPRSS4, but viral particles in stool are inactivated, suggesting limited fecal-oral transmission.

bioRxiv · Apr 21, 2020Microbiology

Rapid dissemination and monopolization of viral populations in mice revealed using a panel of barcoded viruses

B. T. McCune, M. R. Lanahan, B. R. tenOever, J. K. Pfeiffer

This study tracks viral population dynamics in orally infected mice using barcoded coxsackieviruses, revealing rapid dissemination followed by diversity restriction and monopolization in tissues.

bioRxiv · Sep 16, 2019Microbiology

Related enteric viruses have different requirements for host microbiota in mice

C. M. Robinson, M. Woods Acevedo, B. T. McCune, J. K. Pfeiffer

The paper shows that coxsackievirus B3 (CVB3) is more sensitive to antibiotic-induced microbiota depletion than poliovirus, suggesting differences in microbiota reliance among related enteric viruses.

bioRxiv · Aug 13, 2019Microbiology

Caspase-mediated cleavage of murine norovirus NS1/2 potentiates apoptosis and is required for persistent infection of intestinal epithelial cells

B. A. Robinson, J. A. Van Winkle, B. T. McCune, A. M. Peters, T. J. Nice

This study shows that cleavage of NS1/2 by caspases in MNV-infected intestinal epithelial cells promotes apoptosis and is required for persistent infection, but not for acute infection in other cell types.

bioRxiv · Mar 26, 2019Microbiology