J. K. Pfeiffer

Murine norovirus mutants adapted to replicate in human cells reveal a post-entry restriction

This study identifies mutations in murine norovirus that enhance replication in human cells, revealing post-entry restrictions in addition to receptor expression.

CDKL5 regulates p62-mediated selective autophagy and host antiviral defense

This study identifies CDKL5 as a regulator of virophagy, showing it promotes p62-mediated autophagy of viral capsids and enhances antiviral defense.

Bacteria-mediated stabilization of murine norovirus

This study identifies Gram-positive bacteria and bacterial components that stabilize murine norovirus (MNV) virions, suggesting a role for bacteria in enhancing viral stability in the environment.

STING mediates immune responses in the closest living relatives of animals

This study shows that STING mediates antibacterial immunity in the choanoflagellate M. brevicollis, a close relative of animals, and identifies its role in pathogen sensing and autophagy.

Tradeoffs for a viral mutant with enhanced replication speed

This study selects for a faster-replicating coxsackievirus mutant by harvesting early progeny, revealing a tradeoff between replication speed and fitness in different environments.

Microbiota-Independent Antiviral Effects of Antibiotics on Enteric Viruses

This study shows antibiotics reduce systemic enteric virus infection in mice, even in germ-free conditions, suggesting microbiota-independent antiviral effects.

Use of a glycan library reveals a new model for enteric virus oligosaccharide binding and virion stabilization

This study identifies that long GlcNAc polysaccharides stabilize poliovirus by bridging viral capsid proteins, while short oligosaccharides only bind without enhancing stability.

Rapid dissemination and monopolization of viral populations in mice revealed using a panel of barcoded viruses

This study tracks viral population dynamics in orally infected mice using barcoded coxsackieviruses, revealing rapid dissemination followed by diversity restriction and monopolization in tissues.

Related enteric viruses have different requirements for host microbiota in mice

The paper shows that coxsackievirus B3 (CVB3) is more sensitive to antibiotic-induced microbiota depletion than poliovirus, suggesting differences in microbiota reliance among related enteric viruses.

The Antibiotic Neomycin Enhances Coxsackievirus Plaque Formation

This study shows that neomycin, an antibiotic, enhances coxsackievirus plaque formation in vitro without bacterial presence by overcoming sulfated polysaccharide inhibition.

Bacteria-mediated stabilization of a panel of Picornaviruses

This study investigates how bacteria affect the stability of different picornaviruses, finding that some are stabilized by bacteria while others are not.

Bacteria facilitate viral co-infection of mammalian cells and promote genetic recombination

This study shows that intestinal bacteria can enhance viral co-infection and genetic recombination in mammalian cells, improving viral fitness.

Plaques formed by mutagenized viral populations have elevated co-infection frequencies

This study shows that multiple viruses can contribute to plaque formation, with co-infection frequencies increasing in highly mutagenized viral populations.