M. P. Kim

Integrated spatial transcriptomics and lipidomics of precursor lesions of pancreatic cancer identifies enrichment of long chain sulfatide biosynthesis as an early metabolic alteration

Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms of The Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential

This study identifies NKX6-2 as a driver of gastric differentiation in IPMNs, linking its expression to indolent biological potential and progression.

Oncogenic KrasG12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8+ T cells dependent manner

This study shows that MRTX1133, a KrasG12D inhibitor, reduces early pancreatic lesions and, when combined with immunotherapy, regresses advanced PDAC by enhancing CD8+ T cell activity.

DDR1-INDUCED NEUTROPHIL EXTRACELLULAR TRAPS DRIVE PANCREATIC CANCER METASTASIS

This study shows DDR1 signaling in pancreatic cancer cells promotes metastasis by inducing CXCL5 production, which recruits neutrophils to form extracellular traps that facilitate cancer cell invasion.

Single Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression

This study uses single-cell RNA sequencing to analyze transcriptomic changes in pancreatic cancer precursors, revealing epithelial and microenvironmental heterogeneity during progression to cancer.