Transient non-integrative nuclear reprogramming promotes multifaceted reversal of aging in human cells
T. J. Sarkar, M. Quarta, S. Mukherjee, A. Colville, P. Paine, L. Doan, C. M. Tran, C. R. Chu, S. Horvath, N. Bhutani, T. A. Rando, V. Sebastiano
This study shows that transient non-integrative nuclear reprogramming reverses aging in human cells by rejuvenating epigenetic clocks and cellular functions without losing identity.
bioRxiv · Mar 18, 2019Cell Biology