Author

A. Colville

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

T. A. Rando· 2 shared A. Goshayeshi· 1 shared C. M. Tran· 1 shared C. R. Chu· 1 shared D. W. Morgens· 1 shared D. Yao· 1 shared H. D. Ishak· 1 shared J. D. D. Klein· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

T. A. Rando

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2 papers

Recent·Most cited

Death-seq identifies regulators of cell death and senolytic therapies

A. Colville, J.-Y. Liu, S. Thomas, H. D. Ishak, R. Zhou, J. D. D. Klein, D. W. Morgens, A. Goshayeshi, J. S. Salvi, D. Yao, K. Spees, M. C. Bassik, T. A. Rando

Death-seq identifies enhancers of cell death and senolytic therapies through a CRISPR screen, revealing synergistic combinations that clear senescent cells without thrombocytopenia.

bioRxiv · Apr 1, 2022Cell Biology

Transient non-integrative nuclear reprogramming promotes multifaceted reversal of aging in human cells

T. J. Sarkar, M. Quarta, S. Mukherjee, A. Colville, P. Paine, L. Doan, C. M. Tran, C. R. Chu, S. Horvath, N. Bhutani, T. A. Rando, V. Sebastiano

This study shows that transient non-integrative nuclear reprogramming reverses aging in human cells by rejuvenating epigenetic clocks and cellular functions without losing identity.

bioRxiv · Mar 18, 2019Cell Biology