C. Murre

Active maintenance of CD8+ T cell naivety through regulation of global genome architecture

This study shows that transcription factors maintain CD8+ T cell naivety by enforcing a distinct chromatin architecture that remodels upon activation.

A Proposed Unified Mitotic Chromosome Architecture

The paper proposes a unified molecular architecture for human Chromosome 10 throughout the mitotic cycle, based on interphase structure and validated by digital PCR.

A Proposed Unified Interphase Nucleus Chromosome Structure: Preliminary Preponderance of Evidence

The paper proposes a unified interphase nucleus chromosome structure based on cryo-electron tomography, suggesting a coiled 'Slinky' architecture that explains various chromosome structures.

Direct observation of RAG recombinase recruitment to chromatin and the IgH locus in live pro-B cells

The paper uses single-molecule imaging to study RAG recombinase dynamics in live pro-B cells, revealing its search strategy for chromatin and the IgH locus.

Molecular determinants and heterogeneity of tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing

The paper uses single-cell RNA sequencing to study CD8+ T cell differentiation during infection, revealing molecular determinants and functional heterogeneity in tissue-resident memory cells.

Antigen receptor locus dynamics is orchestrated near the sol-gel phase transition to enforce stepwise VDJ gene rearrangement

The paper tracks VH-DHJH motion in B-lymphocytes and finds that constrained local motion and proximity to the sol-gel phase transition enable stepwise VDJ gene rearrangement.

Id proteins suppress E2A-driven innate-like T cell development prior to TCR selection

This study shows that Id proteins suppress E2A-driven innate-like T cell development before TCR selection, promoting conventional T cell dominance.