N. Khanna

A Far-Red Fluorescent Probe to Visualize Staphylococcus aureus in Patient Samples

The paper develops a far-red fluorescent probe to visualize Staphylococcus aureus in human tissue samples, demonstrating its effectiveness in multiple imaging applications.

Stem cell memory EBV-specific T cells control post-transplant lymphoproliferative disease and persist in vivo

This study develops a protocol to expand EBV-specific stem cell memory T cells, showing improved tumor control and persistence in a PTLD model compared to existing ACT methods.

A method for polyclonal antigen-specific T cell-targeted genome editing (TarGET) for adoptive cell therapy applications

The paper introduces a method for CRISPR-targeted genome integration of a barcoded gene into antigen-specific T cells to enhance traceability and monitoring in adoptive cell therapy.

Cocculus hirsutus -derived phytopharmaceutical drug has potent anti-dengue activity

This paper identifies Cocculus hirsutus-derived AQCH as a potent anti-dengue drug with in vitro and in vivo efficacy, characterized by five chemical markers and formulated into tablets for further development.

ARHGEF3 regulates skeletal muscle regeneration and strength through autophagy

This study shows ARHGEF3 promotes muscle regeneration and strength by enhancing autophagy, independent of mTORC2-Akt signaling, in both young and aged mice.

RpiRc regulates RsbU to modulate eDNA-dependent biofilm formation and in vivo virulence of Staphylococcus aureus in a mouse model of catheter infection

This study identifies RpiRc as a regulator of eDNA-dependent biofilm formation and virulence in S. aureus, showing reduced biofilm formation and antibiotic tolerance in its mutant.

Transcription amplification by nuclear speckle association

This study shows that gene positioning near nuclear speckles enhances transcription levels through a mechanism distinct from transcriptional bursting.

Antigen receptor locus dynamics is orchestrated near the sol-gel phase transition to enforce stepwise VDJ gene rearrangement

The paper tracks VH-DHJH motion in B-lymphocytes and finds that constrained local motion and proximity to the sol-gel phase transition enable stepwise VDJ gene rearrangement.