J. K. Lee

PGC-1a drives small cell neuroendocrine cancer progression towards an ASCL1-expressing subtype with increased mitochondrial capacity

Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations

This paper introduces a combinatorial genetic strategy to generate diverse cancer models and uses single-cell sequencing to identify polygenic drivers of cancer phenotypes.

Active maintenance of CD8+ T cell naivety through regulation of global genome architecture

This study shows that transcription factors maintain CD8+ T cell naivety by enforcing a distinct chromatin architecture that remodels upon activation.

Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

This study develops TAG72-CAR T cells with antigen-dependent IL-12 signaling to enhance anti-tumor activity and systemic disease targeting in ovarian cancer.

Compulsivity is linked to maladaptive choice variability but unaltered reinforcement learning under uncertainty

This study links compulsivity to increased choice variability without changes in learning variability under uncertainty.

Adaptive tuning of human learning and choice variability to unexpected uncertainty

This study shows humans adjust exploration and learning precision in response to unexpected uncertainty, demonstrating adaptive tuning of decision-making strategies.

Sniper2L, a high-fidelity Cas9 variant with high activity

This paper develops Sniper2L, a high-fidelity Cas9 variant with improved specificity and retained high on-target activity, and introduces a deep-learning model to predict its activity.

Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell therapy

This study develops STEAP1 CAR T cell therapy for advanced prostate cancer, showing potent antitumor activity and safety in preclinical models, but also identifies antigen loss as a resistance mechanism.

Bile Acid Regulates the Colonization and Dissemination of Candida albicans from the Gastrointestinal Tract by Controlling Host Defense System and Microbiota

This study shows that bile acid TCA promotes Candida albicans colonization and dissemination from the gut by altering host immunity and microbiota.

Nuclear stabilisation of p53 requires a functional nucleolar surveillance pathway

This study identifies the nucleolar surveillance pathway (NSP) as a central regulator of p53 stability, showing its role in integrating various cellular stresses and its potential as a therapeutic target in cancer.

Single molecule analysis of effects of non-canonical guide RNAs and specificity-enhancing mutations on Cas9-induced DNA unwinding

The paper evaluates how non-canonical guide RNAs and Cas9 variants affect DNA unwinding, finding that some combinations reduce off-target activity while maintaining on-target efficiency.

Targeting RET Kinase in Neuroendocrine Prostate Cancer

The paper identifies RET kinase as a targetable driver in neuroendocrine prostate cancer (NEPC) through phosphoproteomics and pharmacological inhibition studies, showing reduced tumor growth in models.

Directed evolution of CRISPR-Cas9 to increase its specificity

This study evolves CRISPR-Cas9 to enhance specificity while maintaining on-target activity in human cells.