Author

C. N. Takacs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1 Assay:imaging· 1

Frequent Co-Authors

C. Jacobs-Wagner· 4 shared M. Scott· 3 shared P. A. Rosa· 3 shared I. Irnov· 2 shared Z. A. Kloos· 2 shared J. E. Haber· 1 shared J. Liu· 1 shared J. Wachter· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersMicrobiology

C. Jacobs-Wagner

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4 papers

Recent·Most cited

Cas9-mediated endogenous plasmid loss in Borrelia burgdorferi

C. N. Takacs, Y. Nakajima, J. E. Haber, C. Jacobs-Wagner

This paper develops a Cas9-based method to remove specific endogenous plasmids from Borrelia burgdorferi and demonstrates its effectiveness in eliminating plasmids like lp25 and lp28-1.

bioRxiv · Sep 22, 2022Microbiology

Polyploidy, regular patterning of genome copies, and unusual control of DNA partitioning in the Lyme disease spirochete

C. N. Takacs, J. Wachter, Y. Xiang, X. Karaboja, R. Zhongqing, M. Scott, M. R. Stoner, I. Irnov, N. Jannetty, P. A. Rosa, X. Wang, C. Jacobs-Wagner

This study shows that Borrelia burgdorferi is polyploid in culture and ticks, with regular genome copy spacing controlled by ParA/ParZ and ParB/SMC systems.

bioRxiv · Jul 5, 2022Microbiology

A CRISPR interference platform for selective downregulation of gene expression in Borrelia burgdorferi

C. N. Takacs, M. Scott, Y. Chang, Z. A. Kloos, I. Irnov, P. A. Rosa, J. Liu, C. Jacobs-Wagner

This paper develops a CRISPR interference platform for efficient gene downregulation in Borrelia burgdorferi, demonstrating >95% repression efficiency for multiple genes and revealing roles in motility and cell division.

bioRxiv · Oct 12, 2020Microbiology

Characterization of fluorescent proteins, promoters, and selectable markers for applications in the Lyme disease spirochete Borrelia burgdorferi

C. N. Takacs, Z. A. Kloos, M. Scott, P. A. Rosa, C. Jacobs-Wagner

The paper develops and characterizes fluorescent proteins, antibiotic selection markers, and promoters for use in Borrelia burgdorferi to enhance genetic tools and study its biology.

bioRxiv · Sep 21, 2018Microbiology