Author

I. Irnov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Assay:DNA methylation· 2 Organism:E. coli· 2 Assay:imaging· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. Jacobs-Wagner· 4 shared C. N. Takacs· 2 shared M. Scott· 2 shared P. A. Rosa· 2 shared A. Pironti· 1 shared B. Beltran· 1 shared B. Shopsin· 1 shared C. Zhou· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersMicrobiology

C. Jacobs-Wagner

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Author profile →

5 papers

Recent·Most cited

Prophage-encoded methyltransferase drives adaptation of community-acquired methicillin-resistant Staphylococcus aureus

R. J. Ulrich, M. Podkowik, R. Tierce, I. Irnov, G. Putzel, N. Samhadaneh, K. A. Lacey, D. Boff, S. M. Morales, S. Makita, T. K. Karagounis, E. E. Zwack, C. Zhou, R. Kim, K. Drlica, , B. Shopsin

This study identifies a prophage-encoded methyltransferase, pamA, that enhances virulence in CA-MRSA by epigenetically upregulating fnbA, promoting biofilm formation and abscess size.

bioRxiv · Apr 17, 2024 · PreprintMicrobiology

Polyploidy, regular patterning of genome copies, and unusual control of DNA partitioning in the Lyme disease spirochete

C. N. Takacs, J. Wachter, Y. Xiang, X. Karaboja, R. Zhongqing, M. Scott, M. R. Stoner, I. Irnov, N. Jannetty, P. A. Rosa, X. Wang, C. Jacobs-Wagner

This study shows that Borrelia burgdorferi is polyploid in culture and ticks, with regular genome copy spacing controlled by ParA/ParZ and ParB/SMC systems.

bioRxiv · Jul 5, 2022Microbiology

A CRISPR interference platform for selective downregulation of gene expression in Borrelia burgdorferi

C. N. Takacs, M. Scott, Y. Chang, Z. A. Kloos, I. Irnov, P. A. Rosa, J. Liu, C. Jacobs-Wagner

This paper develops a CRISPR interference platform for efficient gene downregulation in Borrelia burgdorferi, demonstrating >95% repression efficiency for multiple genes and revealing roles in motility and cell division.

bioRxiv · Oct 12, 2020Microbiology

RNA polymerases display collaborative and antagonistic group behaviors over long distances through DNA supercoiling

S. Kim, B. Beltran, I. Irnov, C. Jacobs-Wagner

The paper shows that RNA polymerases in E. coli exhibit collaborative and antagonistic behaviors due to DNA supercoiling during transcription.

bioRxiv · Oct 3, 2018 · PreprintMicrobiology

Genome-wide phenotypic analysis of growth, cell morphogenesis and cell cycle events in Escherichia coli.

M. Campos, S. K. Govers, I. Irnov, G. S. Dobihal, F. Cornet, C. Jacobs-Wagner

The paper performs a genome-wide screen of Escherichia coli single-gene knockouts to uncover genes involved in cell morphogenesis, growth, and cell cycle, revealing scaling relationships between nucleoid size and cell cycle events.

bioRxiv · Apr 9, 2018Microbiology