Temporal inhibition of autophagy reveals segmental reversal of aging with increased cancer risk
L. Cassidy, A. R. Young, C. N. Young, E. J. Soilleux, E. Fielder, B. M. Weigand, R. Brais, K. A. Wiggins, M. C. Clarke, D. Jurk, J. F. Passos, M. Narita
This study shows that inhibiting autophagy in mammals accelerates aging and increases cancer risk, while restoring autophagy extends lifespan but does not fully prevent cancer.
bioRxiv · Jan 23, 2019 · PreprintCancer Biology