E. Fielder

Mild uncoupling of mitochondria synergistically enhances senolytic specificity and sensitivity of BH3 mimetics

This study shows that mild mitochondrial uncoupling enhances the senolytic effectiveness of BH3 mimetics in vitro and in vivo by targeting senescent cell vulnerabilities.

Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

The paper shows that short anti-senescence interventions reduce radiation-induced frailty and premature ageing in mice, improving muscle, liver function, and memory.

Temporal inhibition of autophagy reveals segmental reversal of aging with increased cancer risk

This study shows that inhibiting autophagy in mammals accelerates aging and increases cancer risk, while restoring autophagy extends lifespan but does not fully prevent cancer.

Length-independent telomere damage drives cardiomyocyte senescence

This study shows that telomere damage independent of length causes cardiomyocyte senescence, leading to cardiac dysfunction, and that clearing senescent cells improves cardiac health.