Author

M. Mellado

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

B. Soler Palacios· 2 shared E. M. Garcia-Cuesta· 2 shared J. M. Rodriguez Frade· 2 shared P. Lucas· 2 shared A. Cayuela· 1 shared A. Garcia-Rubia· 1 shared A. M. Gomez Pozo· 1 shared A. Martinez· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCell Biology

B. Soler Palacios

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain

E. M. Garcia-Cuesta, P. Martinez, K. Selvaraju, G. Ulltjärn, A. M. Gomez Pozo, G. D'Agostino, S. Gardeta, A. Quijada-Freire, P. Blanco Gabella, C. Roca, D. del Hoyo, R. Jimenez-Saiz, A. Garcia-Rubia, B. Soler Palacios, P. Lucas, , M. Mellado

This paper identifies a small molecule that modulates CXCR4 nanoclustering without affecting ligand binding, improving therapeutic potential over existing CXCR4 antagonists.

bioRxiv · Nov 19, 2023Cell Biology

Growth hormone remodels the 3D-structure of the mitochondria of inflammatory macrophages and promotes metabolic reprogramming

B. Soler Palacios, R. Villares, P. Lucas, J. M. Rodriguez Frade, A. Cayuela, J. G. Piccirillo, D. Delgado Gestoso, C. Risco, F. Corrales, C. O. S. Sorzano, N. Martinez, J. J. Conesa, F. J. Iborra, M. Mellado

This study shows growth hormone remodels mitochondrial structure and promotes metabolic reprogramming in inflammatory macrophages.

bioRxiv · Aug 22, 2022Immunology

Pre-TCR signaling intensity shapes the TCRβ repertoire

E. R. Bovolenta, E. M. Garcia-Cuesta, J. Ponomarenko, M. Mellado, M. Castro, D. Abia, H. M. van Santen

The paper shows that pre-TCR signaling intensity affects TCRβ repertoire diversity in murine thymocytes by influencing nanoclustering and maturation.

bioRxiv · May 4, 2020 · PreprintImmunology