HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-kB/IRF3 nuclear transport
H. Khan, R. P. Sumner, J. Rasaiyaah, C. P. Tan, M. T. Rodriguez-Plata, C. Van Tulleken, D. Fink, L. Zuliani-Alvarez, L. Thorne, D. Stirling, R. S. B. Milne, G. J. Towers
This study shows HIV-1 Vpr inhibits IRF3 and NF-κB nuclear transport by interacting with karyopherins, thereby evading innate immune activation and promoting HIV-1 replication in macrophages.
bioRxiv · Feb 22, 2020Microbiology