H. Khan

Long non-coding RNAs regulate the expression of cell surface receptors in plants

This study identifies cis-NATs as key regulators of LRR-RLK expression and function in plants, showing their conserved role across plant evolution.

Characterization of the novel SmsHSP24.1 Promoter: Unveiling its abiotic stress-inducible expression in transgenic Eggplant (Solanum melongena L.)

This study characterizes the SmsHSP24.1 promoter in eggplant, showing its inducible expression under abiotic stresses and its potential as a tool for crop improvement.

IN VITRO 5-LOX INHIBITORY POTENTIAL AND ANTIOXIDANT ACTIVITY OF NEW ISOXAZOLE DERIVATIVES

This paper evaluates the 5-LOX inhibitory and antioxidant activity of new isoxazole derivatives in vitro, identifying C3 as the most potent compound.

The complement pattern recognition molecule CL-11 promotes invasion and injury of respiratory epithelial cells by SARS-CoV-2.

This study shows CL-11 promotes SARS-CoV-2 invasion and injury of respiratory epithelial cells, suggesting CL-11 blockade could limit viral pathogenicity.

Activation-induced shift in nutrient preference and function-specific nutrient dependence in human neutrophils

This study shows that human neutrophils shift nutrient preference from glycogen to glucose upon activation, with function-specific metabolic dependencies.

Chitinase 3-like-1 (CHI3L1) in the Pathogenesis of Epidermal Growth Factor Receptor Mutant Non-Small Cell Lung Cancer

This study shows CHI3L1 is induced by EGFR activation in NSCLC and promotes EGFR signaling, with anti-CHI3L1 antibodies reversing TKI resistance and inhibiting metastasis.

Evolutionary fingerprints of EMT in pancreatic cancers

This study investigates the role of EMT in pancreatic cancer evolution and metastasis, showing that mesenchymal lineages drive chromosomal instability and clonal evolution.

Plant PAXX has an XLF-like function and stimulates DNA end-joining by the Ku-DNA ligase IV-XRCC4 complex

The paper identifies a plant PAXX ortholog that functions similarly to human XLF in DNA end-joining by interacting with Ku and XRCC4, suggesting evolutionary merging of PAXX and XLF roles in plants.

Dual functioning by the PhoR sensor is a key determinant to Mycobacterium tuberculosis virulence

This study identifies PhoR as a dual-function sensor kinase/phosphatase in M. tuberculosis, revealing its role in virulence through pH and salt sensing and regulation of the PhoP regulon.

Development and qualification of a high-yield recombinant human Erythropoietin biosimilar

This paper develops and characterizes a high-yield biosimilar of recombinant human erythropoietin (rhEPO) that meets regulatory requirements and offers a cost-effective alternative.

A Cost-effective Purification Process for Erythropoietin Biosimilar through Downstream Process Engineering

This study develops a scalable and reproducible downstream purification process for EPO biosimilar, meeting quality requirements and reducing production costs.

Convergence of two global regulators to coordinate expression of essential virulence determinants of Mycobacterium tuberculosis

The paper identifies a regulatory mechanism where CRP and PhoP co-activate virulence genes in M. tuberculosis through protein-protein interactions and promoter recruitment.

CHI3L1 Enhances Melanoma Lung Metastasis via Regulation of T cell Co-stimulators and CTLA-4/B7 Axis

This study shows CHI3L1 promotes melanoma lung metastasis by inhibiting T cell co-stimulators and stimulating CTLA-4/B7 axis, with combined anti-CHI3L1 and anti-CTLA-4 antibodies showing synergistic antitumor effects.

Mycobacterium tuberculosis PhoP integrates stress response to intracellular survival by regulating cAMP level

The paper identifies PhoP's role in regulating cAMP levels in M. tuberculosis by repressing the PDE Rv0805, affecting stress response and intracellular survival.

Molecular connectivity between extra-cytoplasmic sigma factors and PhoP accounts for integrated mycobacterial stress response

This study investigates how PhoP interacts with sigma factors to regulate mycobacterial stress responses under different conditions, revealing distinct roles in pH and redox homeostasis.

TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction

This study shows that NCOA7 restricts SARS-CoV-2 infection by promoting endosomal acidification, and TMPRSS2 or removal of the furin cleavage site reduces this restriction.

Impact of the B.1.1.7 variant on neutralizing monoclonal antibodies recognizing diverse epitopes on SARS-CoV-2 Spike

This study examines how mutations in the B.1.1.7 variant of SARS-CoV-2 affect neutralization by monoclonal antibodies targeting non-RBD epitopes.

BANCOVID, the first D614G variant mRNA-based vaccine candidate against SARS-CoV-2 elicits neutralizing antibody and balanced cellular immune response

This paper develops and characterizes an mRNA-LNP vaccine candidate targeting the D614G variant of SARS-CoV-2, showing neutralizing antibody and balanced cellular immune responses in preclinical trials.

HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-kB/IRF3 nuclear transport

This study shows HIV-1 Vpr inhibits IRF3 and NF-κB nuclear transport by interacting with karyopherins, thereby evading innate immune activation and promoting HIV-1 replication in macrophages.