Author

L. Thorne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

G. J. Towers· 2 shared A. Garcia-Sastre· 1 shared A. S. Jahun· 1 shared A.-K. Reuschl· 1 shared C. Borg· 1 shared C. Jolly· 1 shared C. P. Tan· 1 shared C. Van Tulleken· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMicrobiology

G. J. Towers

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant

A.-K. Reuschl, L. Thorne, L. Zuliani Alvarez, M. Bouhaddou, K. Obernier, J. Hiatt, M. Soucheray, J. Turner, J. Fabius, G. T. Nguyen, D. Swaney, R. Rosales, K. M. White, P. Aviles, I. T. Kirby, , N. J. Krogan

This study evaluates the efficacy of host-directed therapies against the B.1.1.7 SARS-CoV-2 variant and finds similar antiviral activity compared to early-lineage SARS-CoV-2.

bioRxiv · Jan 24, 2021 · PreprintMicrobiology

HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-kB/IRF3 nuclear transport

H. Khan, R. P. Sumner, J. Rasaiyaah, C. P. Tan, M. T. Rodriguez-Plata, C. Van Tulleken, D. Fink, L. Zuliani-Alvarez, L. Thorne, D. Stirling, R. S. B. Milne, G. J. Towers

This study shows HIV-1 Vpr inhibits IRF3 and NF-κB nuclear transport by interacting with karyopherins, thereby evading innate immune activation and promoting HIV-1 replication in macrophages.

bioRxiv · Feb 22, 2020Microbiology

Murine norovirus virulence factor 1 (VF1) protein contributes to viral fitness during persistent infection

C. Borg, A. S. Jahun, L. Thorne, F. Sorgeloos, D. Bailey, I. Goodfellow

This study shows that VF1 in MNV contributes to viral fitness during persistent infection but is not essential for persistence.

bioRxiv · May 23, 2019Microbiology