Author

C. R. Caffrey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:imaging· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

E. Criado-Hidalgo· 2 shared J. C. del Alamo· 2 shared J. C. Lasheras· 2 shared S. Zhang· 2 shared Y.-T. Yeh· 2 shared A. Brancale· 1 shared A. Garcia-De Herreros· 1 shared A. J. O'Donoghue· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

E. Criado-Hidalgo

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolopyrimidines as Potential Candidates to Treat Human African Trypanosomiasis

L. Monti, L. J. Liu, C. Varricchio, B. Lucero, T. Alle, W. Yang, I. Bem-Shalom, M. Gilson, K. R. Brunden, A. Brancale, C. R. Caffrey, C. Ballatore

This study evaluates the structure-activity relationships, tolerability, and efficacy of microtubule-active triazolopyrimidines against Trypanosoma brucei, identifying two congeners with significant antiparasitic effects in vivo.

bioRxiv · Mar 11, 2023Microbiology

Biomechanical interactions of Schistosoma mansoni eggs with vascular endothelial cells facilitate egg extravasation

Y.-T. Yeh, D. E. Skinner, E. Criado-Hidalgo, N. S. Chen, A. Garcia-De Herreros, N. El-Sakary, L. Liu, S. Zhang, S. Chien, J. C. Lasheras, J. C. del Alamo, C. R. Caffrey

This study investigates how Schistosoma mansoni eggs interact biomechanically with vascular endothelial cells to facilitate their extravasation from blood vessels.

bioRxiv · Sep 16, 2021Microbiology

A multi-dimensional, time-lapse, high content screening platform applied to schistosomiasis drug discovery

S. Chen, B. M. Suzuki, J. Dohrmann, R. Singh, M. R. Arkin, C. R. Caffrey

The paper develops a high-content screening platform to analyze schistosomiasis drug responses and identifies new bioactive compounds.

bioRxiv · Oct 6, 2020 · PreprintMicrobiology

A single-cell RNAseq atlas of the pathogenic stage of Schistosoma mansoni identifies a key regulator of blood feeding

G. Wendt, L. Zhao, R. Chen, C. Lu, A. J. O'Donoghue, C. R. Caffrey, J. Collins

This study uses single-cell RNAseq to analyze adult Schistosoma mansoni parasites, identifying a key regulator of blood feeding and gut maintenance.

Science · Sep 25, 2020Peer-reviewedMicrobiology

Quantifying the mechanics of locomotion of the schistosome pathogen with respect to changes in its physical environment

S. Zhang, D. Skinner, P. Joshi, E. Criado-Hidalgo, Y.-T. Yeh, J. C. Lasheras, C. R. Caffrey, J. C. del Alamo

This study quantifies the biomechanics of schistosome locomotion in different physical environments and identifies key motility parameters that could inform drug development.

bioRxiv · Apr 5, 2019Biophysics