Author

S. Chien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biophysics· 2 Biochemistry· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Assay:imaging· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Y. Wang· 3 shared J. C. del Alamo· 2 shared J. C. Lasheras· 2 shared L. Liu· 2 shared L. Zhu· 2 shared T. Liu· 2 shared Y. Liu· 2 shared Y. Pan· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBioengineering

Y. Wang

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Spatiotemporal Control of Genomics and Epigenomics by Ultrasound

Y. Wu, Z. Huang, Y. Liu, C.-W. Yoon, K. Sun, Y. Situ, P. Ho, Z. Yuan, L. Zhu, J. Eyquem, Y. Zhao, T. Liu, G. A. Kwong, S. Chien, Y. Wang

This paper develops FUS-CRISPR(a/i) tools to remotely control gene expression and epigenetic modifications in vivo, showing therapeutic effects in tumor models.

bioRxiv · Jun 21, 2023 · PreprintBioengineering

Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia

G. Qin, J. Dai, S. Chien, T. J. Martins, B. Loera, Q. Nguyen, M. L. Oakes, B. Tercan, B. Aguilar, L. Hagen, J. McCune, R. Gelinas, R. J. Monnat, I. Shmulevich, P. S. Becker

The paper identifies mutation patterns linked to drug sensitivity in AML using integrated computational and experimental analysis.

bioRxiv · May 24, 2023Cell Biology

Mechanosensor Piezo1 Mediates Bimodal Patterns of Intracellular Signaling

Y. Pan, L. Z. Shi, D. Preece, V. Gomez-Godinez, C. W. Yoon, S. Lu, C. Carmona, S.-H. Woo, S. Chien, M. W. Berns, L. Liu, Y. Wang

This study reveals a bimodal pattern of Piezo1-mediated intracellular calcium and FAK signaling, dependent on the degree of Piezo1 activation.

bioRxiv · May 19, 2022 · PreprintBiophysics

Expression and functional evaluation of recombinant human ABO blood group antigen cleaving glycoside hydrolases α-N-acetylgalactosaminidase, α-galactosidase, and endo-β-galactosidase produced in Escherichia coli

W. H. Toh, Y. Kuo, S. K. Hsu, B. Chen, A. J. Lee, E. Liaw, J. Lee, A. Cheng, L. Hwa, K. Hu, S. Chien, C. Wong, K. Chang, M. Hang, S. Hong, , J. Hsu

This study evaluates recombinant glycoside hydrolases for converting A, B, and AB blood types to O by cleaving surface antigens, showing partial success in porcine red blood cells.

bioRxiv · May 4, 2022 · PreprintBiochemistry

Biomechanical interactions of Schistosoma mansoni eggs with vascular endothelial cells facilitate egg extravasation

Y.-T. Yeh, D. E. Skinner, E. Criado-Hidalgo, N. S. Chen, A. Garcia-De Herreros, N. El-Sakary, L. Liu, S. Zhang, S. Chien, J. C. Lasheras, J. C. del Alamo, C. R. Caffrey

This study investigates how Schistosoma mansoni eggs interact biomechanically with vascular endothelial cells to facilitate their extravasation from blood vessels.

bioRxiv · Sep 16, 2021Microbiology

A balance between matrix deformation and the coordination of turning events governs directed neutrophil migration in 3-D matrices

J. Francois, A. Kandasamy, Y.-T. Yeh, C. Ayala, R. Meili, S. Chien, J. C. Lasheras, J. C. del Alamo

This study shows that neutrophils balance matrix deformation and turning to navigate 3-D collagen matrices, with myosin-II and Arp2/3 playing key roles in this process.

bioRxiv · Sep 2, 2020Biophysics

Acoustogenetic Control of CAR T Cells via Focused Ultrasound

Y. WU, Y. Liu, Z. Huang, X. Wang, Z. Jin, J. Li, P. Limsakul, L. Zhu, M. Allen, Y. Pan, R. Bussell, A. Jacobson, T. Liu, S. Chien, Y. Wang

This paper develops an acoustogenetic method using focused ultrasound to control CAR T cells, enabling noninvasive activation to treat cancer with reduced off-tumor effects.

bioRxiv · Feb 18, 2020Bioengineering