Author

L. J. Liu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. J. O'Donoghue· 2 shared P. Fajtova· 2 shared Z. Jiang· 2 shared A. Brancale· 1 shared A. Syed· 1 shared B. Hurysz· 1 shared B. Lucero· 1 shared C. Ballatore· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

A. J. O'Donoghue

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Author profile →

3 papers

Recent·Most cited

Development of subunit selective proteasome substrates for Schistosoma species

Z. Jiang, E. B. Da Silva, C. Liu, P. Fajtova, L. J. Liu, N. El-Sakkary, D. Skinner, A. Syed, S. C. Wang, C. J. Caffrey, A. J. O'Donoghue

The paper develops subunit-specific proteasome substrates for Schistosoma species, showing improved performance and cross-species applicability.

bioRxiv · Feb 13, 2024 · PreprintBiochemistry

Development of subunit selective substrates for Trichomonas vaginalis proteasome

P. Fajtova, B. Hurysz, Y. Miyamoto, M. Serafim, Z. Jiang, D. F. Trujillo, L. J. Liu, U. Somani, J. Almaliti, S. Myers, C. Caffrey, W. H. Gerwick, C. J. Kirk, E. Boura, L. Eckmann, A. J. O'Donoghue

The paper develops three subunit-specific fluorogenic substrates for the T. vaginalis proteasome and identifies effective inhibitor targets.

bioRxiv · Apr 5, 2023 · PreprintBiochemistry

Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolopyrimidines as Potential Candidates to Treat Human African Trypanosomiasis

L. Monti, L. J. Liu, C. Varricchio, B. Lucero, T. Alle, W. Yang, I. Bem-Shalom, M. Gilson, K. R. Brunden, A. Brancale, C. R. Caffrey, C. Ballatore

This study evaluates the structure-activity relationships, tolerability, and efficacy of microtubule-active triazolopyrimidines against Trypanosoma brucei, identifying two congeners with significant antiparasitic effects in vivo.

bioRxiv · Mar 11, 2023Microbiology